<p>Women’s participation in politics is vital for inclusive decision-making and development. In Ghana’s Upper West Region (UWR), traditional gender roles and patriarchal culture often limit this participation and shape public perceptions of women in leadership. While existing studies have highlighted barriers to women’s political involvement, the intersection of household dynamics with individual, household, and community predictors to influence these perceptions remains unclear. Guided by intersectionality theory, this study utilized cross-sectional survey data (<i>n</i> = 517) from rural households in the UWR to investigate the factors that affect public perception of women as political leaders through a multilevel analysis using multiple-ordered logistic regression analyses at the individual, household, and community-level predictors. The findings revealed that households led by females, either solely or through joint decision-making, were significantly more likely to express agreement with women’s political leadership than male-headed households. Additionally, the findings showed that the intersection of several individual, household, and community factors influences public support of women’s political leadership. The insights provided by this study underscore that policy interventions aimed at enhancing women’s political participation and leadership can be more effective when they consider how contextually relevant socioeconomic, sociopolitical, and sociocultural factors intersect with gender norms to influence public perceptions.</p>