<p>Workplace Health Promotion Program (WHPP) is of crucial importance to both organizations and their employees, whereas their persistently low participation rates underscore an urgent need to refine health communication strategies. The present study introduces power as a key boundary condition and examines how its interaction with message framing (gain vs. loss) shapes communication effectiveness. Through three sequential experiments, we systematically tested this matching effect and its underlying psychological mechanisms. Study 1 (<i>N</i> = 107) manipulated sense of power via role-play imagination, while Study 2 (<i>N</i> = 134) adopted an experiential recall task. These two studies preliminarily validated the proposed power-framing matching effect and identified processing fluency as a critical mediating mechanism. Study 3 (<i>N</i> = 120) further extended these findings to actual corporate employees, employing a mixed-design paradigm and controlling for trait sense of power. This study not only successfully replicated the power-framing matching effect and the mediating role of processing fluency but also uncovered an extended sequential mediational chain: processing fluency-feeling right. Consistent across all studies, high-power individuals responded more favorably to gain-framed messages, whereas low-power individuals exhibited greater receptivity to loss-framed messages. To our knowledge, this research is the first to empirically validate the power-framing matching effect in the context of organizational health communication, offering valuable theoretical contributions and practical implications for developing targeted health communication strategies tailored to employees’ power status in workplace settings.</p>