<p>Recent research on pornography use has indicated that an individual’s subjective moral beliefs about their use may contribute to shame, particularly shame related to their sexual experiences. However, it is possible that a user’s sense of compassion towards themselves can ameliorate the sexual shame associated with moral disapproval. Thus, this cross-sectional study investigated the extent to which self-compassion moderates the relationship between moral disapproval of pornography and sexual shame in a sample of adult pornography users (<i>N</i> = 500). Findings indicate the relationship between moral disapproval and sexual shame is conditioned on levels of self-compassion (<i>b</i> = 0.089, 95% CI = [0.011, 0.166]). While self-compassion generally corresponded to lower sexual shame, surprisingly, increasing levels of self-compassion exacerbated the relationship between moral disapproval and sexual shame, suggesting moral disapproval attenuated the protective effects of self-compassion. Additional analyses were conducted to disentangle the effects of the individual subscales of self-compassion and explore gender differences, which can inform future research and practice. These findings suggest self-compassion, and particularly, targeting self-judgment for women and isolation for men can be key strategies to protect against sexual shame.</p>