DeepFake is similar to Photoshop for videos. This technology, powered by artificial intelligence (AI), allows the creation of highly realistic manipulated videos and audio. The MENA region has witnessed a surge in internet use, reaching 67.2%. This study investigates the intersection of DeepFake technology and gender-based violence (GBV) in the MENA region, exploring the unique vulnerabilities and impacts faced by women (n = 14, \(\:{\mu\:}_{Age}\) = 32.29 years, \(\:{\sigma\:}_{Age}\) = 6.61 years) from Egypt, Saudi Arabia, Jordan, Morocco, and the UAE. Through in-depth interviews, despite participants’ fear of digital shame/ e-shame, this research focuses on victims’ psychological, social, and professional repercussions. The findings reveal that women in high-visibility occupations are particularly vulnerable due to their extensive online presence. The psychological impacts are profound, often leading to long-term mental health challenges such as anxiety, depression, and posttraumatic stress disorder. Professionally, victims face damage to their reputations, loss of income, and social ostracization, particularly within conservative social contexts. Combining computer-assisted tools with manual analysis provided an additional layer of validity and credibility. The lack of robust legal frameworks and societal support in MENA further exacerbates these impacts, highlighting the urgent need for stronger regulation of online spaces and crimes, as well as increased digital literacy initiatives. A dedicated platform to support vulnerable groups (affected by AI misuse) is needed. Additionally, social media and digital platforms should implement AI filters and blockers to detect and prevent the publication of fabricated content. This study is the first to explore the implications of DeepFake technology for GBV in the MENA region and introduces the term “AI-misuse victims.”