<p>To explore the longitudinal impact of adolescents’ perceptions of epidemic risks and interactive health literacy on their self-transcendence. A 6-month tracking study was conducted among 908 adolescents, utilizing an epidemic risk perception scale, an interactive health literacy questionnaire, and an adolescent self-transcendence scale. The results show that (1) Interactive health literacy and self-transcendence of adolescents significantly increased, while the perception of epidemic risks significantly decreased. Equivalence testing showed that the cross-lagged model is applicable across adolescents of different school ages; (2) Both epidemic risk perception and interactive health literacy at the beginning of release of epidemic lockdown significantly predicted the self-transcendence of adolescents six months later, and there was no significant difference in the effects of the two on the self-transcendence of adolescents half a year later; (3) In the cross-lag network, susceptibility and physical activity had the highest impact on in-expected influence of self-transcendence. In conclusion, our study offers a different perspective on the potential value of epidemic risk, which can be an opportunity for self-transcendence if adolescents are proactive in responding to it.</p>