<p>Adolescence is a critical stage of human development characterized by significant physiological, cognitive, and socio-emotional changes, during which individuals are particularly vulnerable to stressors and adversities. This study examined gender-specific differences in experiences of violence, mental health issues, and suicidal behaviors among adolescents. Data from 109,796 respondents to the 2020–2021 Korea Youth Risk Behavior Surveys were analyzed using descriptive statistics, Chi-square tests, and logistic regression. Female adolescents reported significantly higher rates of suicidal ideation, planning, and attempts than did male adolescents. Conversely, experiences of violence were more common among males, whereas stress, depression, loneliness, and anxiety were more prevalent among females. Depression, anxiety, and experiences of violence were significant predictors of suicidal behaviors in both genders. Female adolescents face greater risks of suicidal behaviors, depression, and anxiety than do male adolescents, and experiences of violence significantly impact suicidal behaviors in both genders. These findings highlight the importance of implementing gender-specific approaches to suicide prevention, with targeted interventions addressing violence, depression, and anxiety, particularly among female adolescents. Further research using validated tools is essential to inform the development of equitable and effective policies and practices.</p>