<p>This study investigated relations between demographic factors, conflict orientation (i.e., favoring Israel, Palestine, or ambivalent), and psychological well-being in response to the Israel-Palestine conflict. We assessed whether age, gender, race, and socioeconomic status related to individuals’ (<i>N</i> = 484; 91% US citizens; 65.90% White; January 2024) conflict orientation and their subsequent mental health. Further, we examined whether ethnocultural empathy helped explain individuals’ distress and psychological well-being in response to the conflict. Results indicated that older individuals with higher education and income were more likely to report support for Israel, while those with greater ethnocultural empathy and conflict distress supported Palestine. Notably, most participants expressed ambivalence. However, those reporting an ambivalent conflict orientation also reported heightened conflict distress, which contributed to feelings of anxiety and depression. Understanding these dynamics highlights the interconnections between demographic variables, conflict orientation, and mental health outcomes among people with no first-hand exposure to the conflict.</p>