<p>This research examines the dynamics between organizationally prescribed perfectionism (OPP), psychological safety, burnout, depression, and coaching leadership in the context of the South Korean workforce. By applying several theories, we developed a moderated mediation model. This model suggests that psychological safety and burnout act as sequential mediators between OPP and depression, while coaching leadership moderates the relationship between OPP and psychological safety. Our data, collected from 413 employees across four waves using a time-lagged design, support our proposed model. Structural equation modeling revealed that OPP directly and indirectly affects depression via psychological safety and burnout. Furthermore, the impact of OPP on psychological safety is reduced under strong coaching leadership. These findings underscore the need to address perfectionism in the workplaces and highlight the central roles of psychological safety and coaching leadership in enhancing employee resilience and well-being. This study enriches existing literature by bringing together different theoretical frameworks to provide a comprehensive understanding of how perfectionism affects employee outcomes. It also provides practical recommendations for organizations seeking to foster a supportive and thriving work environment amidst increasing demands for perfectionism.</p>