<p>Scholars have argued that both empirically and theoretically, there is significant potential to integrate the study of internal and international migration. Responding to calls for more place-based research in Africa, this study draws on interview data to examine the disruptive effects of migration and the coping strategies adopted by Ghanaian women left behind by internal migrants (<i>n</i> = 23) and international migrants (<i>n</i> = 21). The findings revealed notable differences in the social and economic challenges faced by the two women’s groups, while emotional and child-care challenges remained largely similar. Women whose husbands migrated outside the African continent, particularly when financial remittances were adequate, tended to view themselves as more self-sufficient and autonomous. To navigate the challenges posed by their husbands’ absence, participants employed a range of coping mechanisms, including engaging in income-generating activities, strengthening social ties, utilizing social media, watching television, and having children, among other strategies. Women whose spouses migrated within Ghana or to other African countries reported using largely similar coping strategies compared to those whose husbands migrated outside Africa. The study concludes by discussing its policy implications.</p>