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<p>Measurement of biological age provides a means to quantify the aging process; however, its relationship with quality of Life in middle-aged adults remains underexplored. This study aimed to evaluate the correlation between biological age and quality of Life in adults aged 30 to 60 years. This cross-sectional study included participants of both genders. Data collected included sociodemographic information, medical history, anthropometric measurements, vital signs, musculoskeletal tests, subjective well-being assessments, and periodontal and paraclinical evaluations. Biological age was estimated using two.&#xa0;(i) a functional capacity algorithm and (ii) the Klemera-Doubal method. The correlation between biological age and quality of life—assessed using the World Health Organization Quality of Life Instrument (WHOQOL-BREF)—was analyzed using Pearson’s correlation and a multiple Linear regression model. A total of 125 participants were included, with a mean chronological age of 45.1 ± 9.4 years and a mean biological age of 47.1 ± 10 years; 46.4% were women. A significant negative correlation was found between biological age and overall quality of life (<i>r</i> = -0.534, <i>p</i> &lt; 0.001; β = -732.5; 95% CI: -994.7 to -520.3; adjusted R² = 0.399, <i>p</i> &lt; 0.001), as well as across all quality of Life domains. Each year of biological age exceeding chronological age was associated with a 27-point decrease in quality of life score. In conclusion, greater biological aging is associated with lower quality of life in middle-aged adults. Early identification of accelerated aging could lead to timely interventions aimed at improving quality of life and promoting healthy longevity.</p>

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Relationship Between Biological Age and Quality of Life in Middle-Aged Adults: A Cross-Sectional Study

  • 期刊论文

  • 发表日期：

    2025年10月4日

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  • Diego Espíndola-Fernández,
  • Oscar Mauricio Gómez-Guzmán,
  • Ana Posada-Cano,
  • Manuela López-Llano,
  • Marcela Osorio-Parra,
  • Juan G. McEwen,
  • Carlos López-Jaramillo,
  • Jaime Gallo-Villegas,
  • Dagnovar Aristizábal-Ocampo

摘要

Measurement of biological age provides a means to quantify the aging process; however, its relationship with quality of Life in middle-aged adults remains underexplored. This study aimed to evaluate the correlation between biological age and quality of Life in adults aged 30 to 60 years. This cross-sectional study included participants of both genders. Data collected included sociodemographic information, medical history, anthropometric measurements, vital signs, musculoskeletal tests, subjective well-being assessments, and periodontal and paraclinical evaluations. Biological age was estimated using two. (i) a functional capacity algorithm and (ii) the Klemera-Doubal method. The correlation between biological age and quality of life—assessed using the World Health Organization Quality of Life Instrument (WHOQOL-BREF)—was analyzed using Pearson’s correlation and a multiple Linear regression model. A total of 125 participants were included, with a mean chronological age of 45.1 ± 9.4 years and a mean biological age of 47.1 ± 10 years; 46.4% were women. A significant negative correlation was found between biological age and overall quality of life (r = -0.534, p < 0.001; β = -732.5; 95% CI: -994.7 to -520.3; adjusted R² = 0.399, p < 0.001), as well as across all quality of Life domains. Each year of biological age exceeding chronological age was associated with a 27-point decrease in quality of life score. In conclusion, greater biological aging is associated with lower quality of life in middle-aged adults. Early identification of accelerated aging could lead to timely interventions aimed at improving quality of life and promoting healthy longevity.