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Objectives <p>This study aimed to investigate the clinicopathological features of malignant odontogenic tumors (MOTs) and to provide a comprehensive characterization that enhances the current understanding of this disease group.</p> Methods <p>MOTs were retrieved from six Brazilian oral pathology services between 2007 and 2025. Demographic, clinical and radiographic data were collected from the charts, and the histological H&amp;E-stained sections were revised by two blinded pathologists; previously available immunohistochemical and molecular findings were retrieved and reviewed in selected cases and the diagnosis was established according to the 2022 World Health Organization classification.</p> Results <p>A total of 53 malignant odontogenic tumors were identified, predominantly affecting the mandible (83%), with a slight male predominance (male-to-female ratio, 1.12:1) and a mean age of 41.4&#xa0;years. Ameloblastic carcinoma was the most frequent subtype (58.5%), followed by clear cell odontogenic carcinoma (18.9%), ameloblastic fibrosarcoma (13.2%), primary intraosseous carcinoma (7.5%), and ghost cell odontogenic carcinoma (1.9%).</p> Conclusions <p>This multicenter review summarizes the main features of malignant odontogenic tumors. Although rare, these tumors often exhibit locally aggressive behavior, highlighting the need for early diagnosis, accurate histopathological evaluation, and standardized reporting with long-term follow-up.</p>

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Malignant Odontogenic Tumors: A Clinicopathological Study of 53 Cases in Brazil

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月21日

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  • Lorena Paula de Paula,
  • Flávia Sirotheau Correa Pontes,
  • Felipe Paiva Fonseca,
  • Pablo Agustin Vargas,
  • Marcio Ajudarte Lopes,
  • Alan Roger dos Santos Silva,
  • Jacks Jorge Júnior,
  • Paulo Victor Mendes Penafort,
  • Adalberto Mosqueda-Taylor,
  • Paulo Sérgio da Silva Santos,
  • Vanessa Soares Lara,
  • Cléverson Teixeira Soares,
  • Décio dos Santos Pinto Júnior,
  • Ramon Ribeiro,
  • Elismauro Francisco de Mendonça,
  • Diego Antônio Costa Arantes,
  • Eneida Franco Vencio,
  • Izadora Fernanda Veiga de Jesus Costa,
  • Flávia Caló de Aquino Xavier,
  • Jean Nunes dos Santos,
  • Rogério Gondak,
  • Filipe Modolo Siqueira,
  • Juliana Lucena Schussel,
  • Heliton Gustavo de Lima,
  • Ciro Dantas Soares,
  • Hélder Antônio Rebelo Pontes

摘要

Objectives

This study aimed to investigate the clinicopathological features of malignant odontogenic tumors (MOTs) and to provide a comprehensive characterization that enhances the current understanding of this disease group.

Methods

MOTs were retrieved from six Brazilian oral pathology services between 2007 and 2025. Demographic, clinical and radiographic data were collected from the charts, and the histological H&E-stained sections were revised by two blinded pathologists; previously available immunohistochemical and molecular findings were retrieved and reviewed in selected cases and the diagnosis was established according to the 2022 World Health Organization classification.

Results

A total of 53 malignant odontogenic tumors were identified, predominantly affecting the mandible (83%), with a slight male predominance (male-to-female ratio, 1.12:1) and a mean age of 41.4 years. Ameloblastic carcinoma was the most frequent subtype (58.5%), followed by clear cell odontogenic carcinoma (18.9%), ameloblastic fibrosarcoma (13.2%), primary intraosseous carcinoma (7.5%), and ghost cell odontogenic carcinoma (1.9%).

Conclusions

This multicenter review summarizes the main features of malignant odontogenic tumors. Although rare, these tumors often exhibit locally aggressive behavior, highlighting the need for early diagnosis, accurate histopathological evaluation, and standardized reporting with long-term follow-up.