Background <p>Salivary gland neoplasms encompass a broad spectrum of morphologic patterns, immunophenotypes, and molecular alterations, and demonstrate overlap with other head and neck tumors and tumors from different lines of differentiation. In routine practice, this overlap is most problematic in small or superficial biopsies, where sampling limitations, biopsy orientation, surface squamopapillary change, stromal predominance, or an unrecognized non-salivary primary can lead to diagnostic misclassification.</p> Discussion and Conclusion <p>This review focuses on select scenarios in which salivary gland neoplasms mimic other entities, as well as situations in which non-salivary gland tumors are mistaken for primary salivary gland lesions. Recognizing these possibilities allows clinical information, histomorphology, immunohistochemistry, and molecular testing to be integrated in a diagnostically meaningful way.</p>