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<p>Intraosseous plexiform schwannoma of the jaw is exceedingly rare, with only one previously reported case in the maxilla. We present a case of a 27-year-old male who presented with a painless maxillary swelling. Radiographic findings reveal an unilocular radiolucent lesion mimicking an odontogenic tumor or cyst. Histopathologic examination showed a multinodular spindle cell neoplasm showing Antoni A and B patterns and diffuse S100 positivity, confirming the diagnosis of intraosseous plexiform schwannoma. Although rare, this entity can mimic an odontogenic lesion on imaging. Awareness of this possibility is crucial to expand the differential diagnosis of radiolucencies of the jaw, and this case underscores the importance of histopathologic assessment for accurate diagnosis and appropriate clinical management.</p>

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Maxillary Intraosseous Plexiform Schwannoma: A Rare Neoplasm Radiographically Imitating an Odontogenic Lesion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月14日

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  • Kittiphoj Tikkhanarak,
  • Emily Lanzel,
  • Sherry Timmons,
  • John Hellstein,
  • Thomas Heidenreich,
  • Nidhi Handoo

摘要

Intraosseous plexiform schwannoma of the jaw is exceedingly rare, with only one previously reported case in the maxilla. We present a case of a 27-year-old male who presented with a painless maxillary swelling. Radiographic findings reveal an unilocular radiolucent lesion mimicking an odontogenic tumor or cyst. Histopathologic examination showed a multinodular spindle cell neoplasm showing Antoni A and B patterns and diffuse S100 positivity, confirming the diagnosis of intraosseous plexiform schwannoma. Although rare, this entity can mimic an odontogenic lesion on imaging. Awareness of this possibility is crucial to expand the differential diagnosis of radiolucencies of the jaw, and this case underscores the importance of histopathologic assessment for accurate diagnosis and appropriate clinical management.