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<p><i>CDK4/MDM2</i> co-amplification, a molecular aberration predominantly observed in sarcomas, has not been previously reported in odontogenic neoplasms. We present the first documented case of odontogenic carcinoma with <i>CDK4/MDM2</i> co-amplification. The tumor exhibited distinctive histologic features including irregular luminal/cleft structures lined by monolayer epithelium over whorled stromal cores. This case expands both the histopathological spectrum and molecular landscape of odontogenic carcinomas. Furthermore, our findings support routine molecular profiling for rare odontogenic malignancies to improve classification and suggest potential theraputic targets.</p>

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A Novel Odontogenic Carcinoma with CDK4/MDM2 Co-Amplification: Expanding the Phenotypic Spectrum of Malignant Odontogenic Entities

  • 期刊论文

  • 发表日期：

    2025年7月21日

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  • Mengxin Ren,
  • Jiaxin Yang,
  • Yanan Sun,
  • Shaodong Yang,
  • Li Wang,
  • Jie Cheng,
  • Hui Zhang,
  • Shilu Tu,
  • Tian Xu,
  • Xiaohong Yang,
  • Jiali Zhang

摘要

CDK4/MDM2 co-amplification, a molecular aberration predominantly observed in sarcomas, has not been previously reported in odontogenic neoplasms. We present the first documented case of odontogenic carcinoma with CDK4/MDM2 co-amplification. The tumor exhibited distinctive histologic features including irregular luminal/cleft structures lined by monolayer epithelium over whorled stromal cores. This case expands both the histopathological spectrum and molecular landscape of odontogenic carcinomas. Furthermore, our findings support routine molecular profiling for rare odontogenic malignancies to improve classification and suggest potential theraputic targets.