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Introduction <p>Solitary fibrous tumor (SFT) is a fibroblastic neoplasm of uncertain biological origin that is rare in the tongue.</p> Case Report <p>A 42-year-old woman presented with a painless, submucosal nodule in the tongue. Based on the clinical hypothesis of benign mesenchymal neoplasia, the lesion was excised, and the specimen was submitted for histopathological analysis. Microscopically, a proliferation of spindle cells with a patternless arrangement was observed, separated by dilated and angulated vascular spaces. Immunohistochemical analysis revealed positivity for CD34, CD99, Bcl-2, Ki-67 (&lt; 5%), and negativity for S-100. Additionally, the tumor cells showed a positive nuclear reaction for STAT6. The diagnosis was a solitary fibrous tumor.</p> Conclusions <p>This report presents a case of SFT in the tongue, emphasizing its clinicopathological, microscopic, and immunohistochemical features.</p>

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Solitary Fibrous Tumor of the Tongue: a Case Report

  • 期刊论文

  • 发表日期：

    2025年1月30日

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  • Anne Evelyn Oliveira Moura,
  • Evelyne Pedroza de Andrade,
  • Thiago Coelho Gomes da Silva,
  • Danielle Machado Farias,
  • Pablo Agustin Vargas,
  • Elaine Judite de Amorim Carvalho,
  • Danyel Elias da Cruz Perez

摘要

Introduction

Solitary fibrous tumor (SFT) is a fibroblastic neoplasm of uncertain biological origin that is rare in the tongue.

Case Report

A 42-year-old woman presented with a painless, submucosal nodule in the tongue. Based on the clinical hypothesis of benign mesenchymal neoplasia, the lesion was excised, and the specimen was submitted for histopathological analysis. Microscopically, a proliferation of spindle cells with a patternless arrangement was observed, separated by dilated and angulated vascular spaces. Immunohistochemical analysis revealed positivity for CD34, CD99, Bcl-2, Ki-67 (< 5%), and negativity for S-100. Additionally, the tumor cells showed a positive nuclear reaction for STAT6. The diagnosis was a solitary fibrous tumor.

Conclusions

This report presents a case of SFT in the tongue, emphasizing its clinicopathological, microscopic, and immunohistochemical features.