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<p>KKT23 is a kinetoplastid-specific kinetochore protein that has a C-terminal GCN5-related histone acetyltransferase domain that acetylates the C-terminal tail of histone H2A. Here, we present the <sup>1</sup>H, <sup>13</sup>C and <sup>15</sup>N resonance assignments for the C-terminal region of KKT23 (KKT23<sup>125–348</sup>) from <i>Trypanosoma brucei</i> in complex with known cofactors for acetyltransferases, acetyl coenzyme A and coenzyme A. These assignments provide the starting point for detailed investigation of the structure, dynamics and interactions of KKT23 in solution.</p>

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1H, 13C and 15N resonance assignments for the acetyltransferase domain of the kinetoplastid kinetochore protein KKT23 from Trypanosoma brucei

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月2日

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  • Patryk Ludzia,
  • Charlotte Nugent,
  • Bungo Akiyoshi,
  • Christina Redfield

摘要

KKT23 is a kinetoplastid-specific kinetochore protein that has a C-terminal GCN5-related histone acetyltransferase domain that acetylates the C-terminal tail of histone H2A. Here, we present the 1H, 13C and 15N resonance assignments for the C-terminal region of KKT23 (KKT23125–348) from Trypanosoma brucei in complex with known cofactors for acetyltransferases, acetyl coenzyme A and coenzyme A. These assignments provide the starting point for detailed investigation of the structure, dynamics and interactions of KKT23 in solution.