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Objectives <p>To evaluate the feasibility and clinical characteristics of early enteral nutrition (EN), defined as initiation within 48&#xa0;h of PICU admission, in children with septic shock, and to describe clinical characteristics and outcomes according to timing of EN in a resource-limited setting.</p> Methods <p>A retrospective observational study was conducted at a national tertiary pediatric intensive care unit in Vietnam. Children aged 1 mo to 16 y diagnosed with septic shock were categorized into early EN (≤48 h) and late EN (&gt;48). Baseline characteristics, illness severity, and clinical outcomes were compared between groups. Multivariable analysis and propensity score matching were performed as exploratory approaches to adjust for confounding.</p> Results <p>Among 52 patients, 22 (42.3%) received early EN. Patients in the early EN group had lower baseline illness severity. Early EN was successfully implemented in a substantial proportion of patients without observed severe gastrointestinal complications. Lower mortality and more favorable outcomes, including fewer days of mechanical ventilation and reduced need for renal replacement therapy, were observed in the early EN group. However, these findings should be interpreted cautiously given the retrospective design, small sample size, and potential confounding by indication.</p> Conclusions <p>Early enteral nutrition was feasible and appeared safe in children with septic shock, even in a resource-limited PICU setting. While favorable outcomes were observed, the study does not establish causality, and further prospective studies are needed to confirm these findings.</p>

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Feasibility of Enteral Nutrition in Pediatric Septic Shock at a Tertiary Center in Vietnam

  • 期刊论文

  • 发表日期：

    2026年7月15日

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  • Hung Viet Dau,
  • Khuyen Thi Ngoc Hoang,
  • Kha Manh Ngo,
  • Hanh My Thi Tran,
  • Canh Ngoc Hoang

摘要

Objectives

To evaluate the feasibility and clinical characteristics of early enteral nutrition (EN), defined as initiation within 48 h of PICU admission, in children with septic shock, and to describe clinical characteristics and outcomes according to timing of EN in a resource-limited setting.

Methods

A retrospective observational study was conducted at a national tertiary pediatric intensive care unit in Vietnam. Children aged 1 mo to 16 y diagnosed with septic shock were categorized into early EN (≤48 h) and late EN (>48). Baseline characteristics, illness severity, and clinical outcomes were compared between groups. Multivariable analysis and propensity score matching were performed as exploratory approaches to adjust for confounding.

Results

Among 52 patients, 22 (42.3%) received early EN. Patients in the early EN group had lower baseline illness severity. Early EN was successfully implemented in a substantial proportion of patients without observed severe gastrointestinal complications. Lower mortality and more favorable outcomes, including fewer days of mechanical ventilation and reduced need for renal replacement therapy, were observed in the early EN group. However, these findings should be interpreted cautiously given the retrospective design, small sample size, and potential confounding by indication.

Conclusions

Early enteral nutrition was feasible and appeared safe in children with septic shock, even in a resource-limited PICU setting. While favorable outcomes were observed, the study does not establish causality, and further prospective studies are needed to confirm these findings.