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Objectives <p>To evaluate the effect of omega-3 supplementation on heart rate (HR) control and heart rate variability (HRV) in children with inappropriate sinus tachycardia (IST).</p> Methods <p>This prospective randomized controlled trial included 60 children (aged 12–16 y) diagnosed with IST. Participants were randomized into two groups: Group A received omega-3 supplementation for 3 mo, while Group B received standard follow-up without treatment. Baseline and post-treatment HR, HRV parameters [Standard deviation of NN intervals (SDNN), Root mean square of successive differences (RMSSD), pNN50], and clinical outcomes were assessed using 24-h Holter monitoring and validated scales.</p> Results <p>After 3 mo, the omega-3 group showed significant reductions in maximum HR (from 160.5 ± 17.9 to 142.2 ± 15.7 bpm, <i>p</i> = 0.000) and average HR (from 98.9 ± 4.7 to 90.7 ± 5.5 bpm, <i>p</i> = 0.000). HRV indices also improved significantly: SDNN (<i>p</i> = 0.000), RMSD (<i>p</i> = 0.000), and pNN50 (<i>p</i> = 0.000). In contrast, no significant changes were observed in the control group. Clinical improvement was significantly higher in the omega-3 group (63.3% marked improvement) compared to controls (<i>p</i> &lt;0.001). Obesity (<i>p</i> = 0.049) and pre-hypertension (<i>p</i> &lt;0.001) were associated with poor response to omega-3 therapy. No significant differences in anxiety scores were found between groups.</p> Conclusions <p>Omega-3 supplementation significantly improved HR control and HRV in pediatric IST patients. Obesity and elevated blood pressure may limit treatment efficacy.</p>

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Potential Role of Omega-3 Supplementation in Modulating Symptoms and Holter Parameters in Pediatric Inappropriate Sinus Tachycardia

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Mohamed Ahmed EL-Baz,
  • Somaia Abdel Samie El Wan,
  • Rodina Sobhy Mohamed,
  • Eman Khaled Gouda,
  • Yousra Mohsen Kamal Ali El-Tabakh,
  • Eman Gamal Abdul Rahman

摘要

Objectives

To evaluate the effect of omega-3 supplementation on heart rate (HR) control and heart rate variability (HRV) in children with inappropriate sinus tachycardia (IST).

Methods

This prospective randomized controlled trial included 60 children (aged 12–16 y) diagnosed with IST. Participants were randomized into two groups: Group A received omega-3 supplementation for 3 mo, while Group B received standard follow-up without treatment. Baseline and post-treatment HR, HRV parameters [Standard deviation of NN intervals (SDNN), Root mean square of successive differences (RMSSD), pNN50], and clinical outcomes were assessed using 24-h Holter monitoring and validated scales.

Results

After 3 mo, the omega-3 group showed significant reductions in maximum HR (from 160.5 ± 17.9 to 142.2 ± 15.7 bpm, p = 0.000) and average HR (from 98.9 ± 4.7 to 90.7 ± 5.5 bpm, p = 0.000). HRV indices also improved significantly: SDNN (p = 0.000), RMSD (p = 0.000), and pNN50 (p = 0.000). In contrast, no significant changes were observed in the control group. Clinical improvement was significantly higher in the omega-3 group (63.3% marked improvement) compared to controls (p <0.001). Obesity (p = 0.049) and pre-hypertension (p <0.001) were associated with poor response to omega-3 therapy. No significant differences in anxiety scores were found between groups.

Conclusions

Omega-3 supplementation significantly improved HR control and HRV in pediatric IST patients. Obesity and elevated blood pressure may limit treatment efficacy.