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Objectives <p>To assess the incidence of recurrent episodes of intussusception in children in southern and western India and identify risk factors associated with recurrence.</p> Methods <p>This multicenter observational study was conducted from August 2019 to December 2022 in children with intussusception aged under 2 y admitted to 21 hospitals in four Indian states: Kerala and Karnataka in southern India and Maharashtra and Gujarat in western India. Clinical, epidemiological, and sociodemographic data were collected using structured questionnaires, medical records, and radiological reports. A single follow-up was conducted in July 2023 to assess vital status and the incidence of intussusception recurrence.</p> Results <p>Out of the 1,406 children enrolled with intussusception, 85 were unavailable for follow-up and 55 (4.2%) experienced one or more recurrent episodes during the study period. The median time to the first recurrence was 137 d. The incidence of recurrence was significantly higher in Kerala (40/697; 5.7%) than in the other three states (15/624; 2.4%; <i>p</i> = 0.027). Incessant crying and irritability were significantly more common in recurrent episodes (20/55; 36.4%) than in first episodes (269/1,266; 21.2%; <i>p</i> = 0.009). Radiological reduction was significantly more common in recurrent cases (49/55; 89.1%) than in first-episode cases (988/1,266; 78%; <i>p</i> = 0.039).</p> Conclusions <p>This study reveals regional and clinical factors associated with recurrence of intussusception and highlights the need for region-specific protocols to optimize treatment and minimize the incidence of recurrence. The reasons for the regional disparities in the incidence of recurrence should be investigated.</p>

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Clinicoepidemiological Characteristics of Recurrent Intussusception Among Children Younger than 2 Years Hospitalized in Four States in Southern and Western India

  • 期刊论文

  • 发表日期：

    2025年12月6日

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  • Varsha Sudhir Chaudhary,
  • Anupama Machathi,
  • Namrata Kharat,
  • Prasanna Samuel Premkumar,
  • Ragavi Lingam,
  • Poovarasan Kannan,
  • Venkata Raghava Mohan

摘要

Objectives

To assess the incidence of recurrent episodes of intussusception in children in southern and western India and identify risk factors associated with recurrence.

Methods

This multicenter observational study was conducted from August 2019 to December 2022 in children with intussusception aged under 2 y admitted to 21 hospitals in four Indian states: Kerala and Karnataka in southern India and Maharashtra and Gujarat in western India. Clinical, epidemiological, and sociodemographic data were collected using structured questionnaires, medical records, and radiological reports. A single follow-up was conducted in July 2023 to assess vital status and the incidence of intussusception recurrence.

Results

Out of the 1,406 children enrolled with intussusception, 85 were unavailable for follow-up and 55 (4.2%) experienced one or more recurrent episodes during the study period. The median time to the first recurrence was 137 d. The incidence of recurrence was significantly higher in Kerala (40/697; 5.7%) than in the other three states (15/624; 2.4%; p = 0.027). Incessant crying and irritability were significantly more common in recurrent episodes (20/55; 36.4%) than in first episodes (269/1,266; 21.2%; p = 0.009). Radiological reduction was significantly more common in recurrent cases (49/55; 89.1%) than in first-episode cases (988/1,266; 78%; p = 0.039).

Conclusions

This study reveals regional and clinical factors associated with recurrence of intussusception and highlights the need for region-specific protocols to optimize treatment and minimize the incidence of recurrence. The reasons for the regional disparities in the incidence of recurrence should be investigated.