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Objectives <p>To compare the proportion of children with withdrawal syndrome in sedoanalgesic drug rotation protocol vs. sedoanalgesia with no rotation using Withdrawal Assessment Tool Version-1 (WAT-1).</p> Methods <p>Sixty children one mo to 18 y admitted to the Pediatric Intensive Care Unit (PICU) for mechanical ventilation were randomized into two groups in a 1:1 ratio. The intervention group received a protocolized rotation of sedative and analgesic drugs combination. In contrast, the control group received sedative and analgesic drugs without any rotation for the entire duration of ventilation. In both groups, adequate depth of sedation was achieved by titrating the sedatives using COMFORT-Behavioural (COMFORT-B) scores. The primary outcome assessed was the incidence of withdrawal syndrome as defined by a WAT-1 score <i>≥</i> 3. Secondary outcomes included cumulative doses of midazolam needed as rescue therapy, mechanical ventilation (MV) duration, need for inotropic support, and the length of stay (LOS) in the PICU.</p> Results <p>In the present study, median (IQR) age of patients was 24 (7, 93) mo. There was a reduced incidence (20% vs. 53.3%; <i>P</i> = 0.004) and median duration of withdrawal syndrome (WAT-1 score <i>≥</i> 3) [1 (IQR 0, 2) vs. 0 (IQR 0, 0); <i>P</i> = 0.012] in the intervention group compared to the control group. The need for inotropic support was higher in the intervention group (62.5% vs. 37.5%; <i>P</i> = 0.038). No other statistically significant outcomes were seen.</p> Conclusions <p>The present study showed that protocolised rotation of sedoanalgesic drugs in mechanically ventilated children can result in lower incidence as well as the duration of withdrawal syndrome.</p>

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Sedative and Analgesic Drug Rotation Protocol Versus Non-Rotation Protocol in Mechanically Ventilated Children: A Randomised Controlled Trial

  • 期刊论文

  • 发表日期：

    2025年3月5日

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  • Uppaluri Naga Pradeep Babu,
  • Nisha Toteja,
  • Bharat Choudhary,
  • Kuldeep Singh,
  • Siyaram Didel,
  • Daisy Khera

摘要

Objectives

To compare the proportion of children with withdrawal syndrome in sedoanalgesic drug rotation protocol vs. sedoanalgesia with no rotation using Withdrawal Assessment Tool Version-1 (WAT-1).

Methods

Sixty children one mo to 18 y admitted to the Pediatric Intensive Care Unit (PICU) for mechanical ventilation were randomized into two groups in a 1:1 ratio. The intervention group received a protocolized rotation of sedative and analgesic drugs combination. In contrast, the control group received sedative and analgesic drugs without any rotation for the entire duration of ventilation. In both groups, adequate depth of sedation was achieved by titrating the sedatives using COMFORT-Behavioural (COMFORT-B) scores. The primary outcome assessed was the incidence of withdrawal syndrome as defined by a WAT-1 score ≥ 3. Secondary outcomes included cumulative doses of midazolam needed as rescue therapy, mechanical ventilation (MV) duration, need for inotropic support, and the length of stay (LOS) in the PICU.

Results

In the present study, median (IQR) age of patients was 24 (7, 93) mo. There was a reduced incidence (20% vs. 53.3%; P = 0.004) and median duration of withdrawal syndrome (WAT-1 score ≥ 3) [1 (IQR 0, 2) vs. 0 (IQR 0, 0); P = 0.012] in the intervention group compared to the control group. The need for inotropic support was higher in the intervention group (62.5% vs. 37.5%; P = 0.038). No other statistically significant outcomes were seen.

Conclusions

The present study showed that protocolised rotation of sedoanalgesic drugs in mechanically ventilated children can result in lower incidence as well as the duration of withdrawal syndrome.