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Introduction <p>Up to 30% of patients with differentiated thyroid carcinoma may experience recurrence within the first decade following initial treatment. Therefore, highly sensitive markers such as thyroglobulin (Tg) are vitally important for detecting persistent or recurrent disease and treating it in a timely manner. In our population, there are few epidemiological records with which to validate cut-off points and compare them with other clinicopathological risk factors.</p> Objective <p>To evaluate the relationship between post-total thyroidectomy Tg levels and medium-term recurrence after surgery in patients with papillary thyroid cancer.</p> Materials and methods <p>The levels of non-stimulated thyroglobulin 4–12&#xa0;weeks after surgery were measured in 106 patients treated between 2018 and 2022 in the Surgical Oncology Department.</p> Results <p>The recurrence rate was of 44%. Univariate analysis showed statistical significance for histologic type, ATA risk of recurrence, and thyroglobulin level, but multivariate analysis revealed a positive association only for patients classified as high risk and for those with non-stimulated Tg levels between 1.1 and 10, which is consistent with previous studies.</p> Conclusion <p>Both clinical–pathological risk stratification and levels of unstimulated postoperative serum thyroglobulin are useful for predicting structural recurrence even in settings with a high prevalence of aggressive histological variants. Therefore, active surveillance protocols based on these factors are essential for achieving good long-term outcomes and avoiding unnecessary diagnostic tests or surgical interventions in patients with differentiated thyroid cancer.</p>

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Impact of post-total thyroidectomy thyroglobulin levels on recurrence in patients with differentiated  thyroid cancer at a tertiary care center in Mexico

  • 期刊论文

  • 发表日期：

    2026年7月7日

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  • Ana Victoria Espinosa de los Monteros Gonzalez,
  • Martin Verdin Gonzalez,
  • Jose Antonio Villegas Velazquez

摘要

Introduction

Up to 30% of patients with differentiated thyroid carcinoma may experience recurrence within the first decade following initial treatment. Therefore, highly sensitive markers such as thyroglobulin (Tg) are vitally important for detecting persistent or recurrent disease and treating it in a timely manner. In our population, there are few epidemiological records with which to validate cut-off points and compare them with other clinicopathological risk factors.

Objective

To evaluate the relationship between post-total thyroidectomy Tg levels and medium-term recurrence after surgery in patients with papillary thyroid cancer.

Materials and methods

The levels of non-stimulated thyroglobulin 4–12 weeks after surgery were measured in 106 patients treated between 2018 and 2022 in the Surgical Oncology Department.

Results

The recurrence rate was of 44%. Univariate analysis showed statistical significance for histologic type, ATA risk of recurrence, and thyroglobulin level, but multivariate analysis revealed a positive association only for patients classified as high risk and for those with non-stimulated Tg levels between 1.1 and 10, which is consistent with previous studies.

Conclusion

Both clinical–pathological risk stratification and levels of unstimulated postoperative serum thyroglobulin are useful for predicting structural recurrence even in settings with a high prevalence of aggressive histological variants. Therefore, active surveillance protocols based on these factors are essential for achieving good long-term outcomes and avoiding unnecessary diagnostic tests or surgical interventions in patients with differentiated thyroid cancer.