Scholarlink

<p>Nicotinamide adenine dinucleotide phosphate oxidase 4, abbreviated as NOX4, is a constitutively active member of the NADPH oxidase family. It primarily produces hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and functions in intracellular signal transduction. Recent studies have revealed its aberrant expression across various malignancies. Unlike traditional organ-based summaries, this review critically synthesizes the functional themes of NOX4 in tumor biology, including regulation of proliferation and apoptosis, epithelial–mesenchymal transition and metastasis, metabolic reprogramming, tumor microenvironment, immune modulation, and therapeutic resistance. Particular emphasis is placed on the context-dependent dual role of NOX4 as both a tumor promoter and suppressor, the mechanistic gaps in inhibitor specificity, and the translational challenges. By integrating findings across cancer types, this review aims to provide a critical conceptual framework for understanding NOX4 biology and for developing targeted therapeutic strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Research progress on the expression characteristics, biological functions, and therapeutic potential of NOX4 in malignant tumors: a functional perspective

  • 期刊论文

  • 发表日期：

    2026年6月25日

查看全文
  • Kaixiu wu,
  • Yue Yang,
  • Meng Xu,
  • Jiayan Guo,
  • Ran Wang,
  • Xinyan Tian,
  • Yarong Hu,
  • Xiaping He,
  • Juan Li

摘要

Nicotinamide adenine dinucleotide phosphate oxidase 4, abbreviated as NOX4, is a constitutively active member of the NADPH oxidase family. It primarily produces hydrogen peroxide (H2O2) and functions in intracellular signal transduction. Recent studies have revealed its aberrant expression across various malignancies. Unlike traditional organ-based summaries, this review critically synthesizes the functional themes of NOX4 in tumor biology, including regulation of proliferation and apoptosis, epithelial–mesenchymal transition and metastasis, metabolic reprogramming, tumor microenvironment, immune modulation, and therapeutic resistance. Particular emphasis is placed on the context-dependent dual role of NOX4 as both a tumor promoter and suppressor, the mechanistic gaps in inhibitor specificity, and the translational challenges. By integrating findings across cancer types, this review aims to provide a critical conceptual framework for understanding NOX4 biology and for developing targeted therapeutic strategies.