Background <p>Colorectal cancer (CRC) is considered one of the major global health concerns, often managed with surgical interventions followed by stoma creation. Although stomas are lifesaving, they can significantly affect patients’ physical and psychological well-being, particularly their quality of life (QoL). The prevalence of stoma-related complications and psychosocial challenges highlights the need for multidisciplinary research to inform patient care.</p> Aim <p>This study aims to identify the clinical and psychosocial factors that affect QoL among CRC patients with a stoma.</p> Patients and methods <p>A cross-sectional study was conducted on 84 CRC patients with a colostomy or ileostomy. We used a validated questionnaire assessing QoL, including sleep behavior, self-image, and sexual and social activities. Demographic and tumor data were collected and analyzed using a multiple linear regression model to determine associated factors for stoma-related low QOL in CRC patients (measured as a continuous Stoma-QOL score).</p> Results <p>CRC patients with a stoma showed low QOL with high frequencies reported on several questionnaire items related to anxiety, social interactions, and body image concerns. 61% of patients responded ‘always’ to the item indicating reduced sexual attractiveness, and 47% were frequently concerned about family stress. Multivariate linear regression analysis revealed that low social status, temporary stoma, and longer baseplate retention time were associated with lower QoL, while advanced cancer stage and colostomy were linked to better QoL.</p> Conclusion <p>Despite the mandatory need for a stoma in CRC patients who underwent surgical intervention, it significantly impacts the psychological well-being, with various sociodemographic and clinical factors affecting QoL. Individualized education and follow-up may enhance stoma adaptation and patient well-being.</p>