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Objective <p>Emerging evidence highlights diverse roles of FSTL1 across various malignancies, though its biological significance in bladder carcinogenesis remains unexplored.</p> Methods <p>This study systematically interrogated FSTL1 using multidimensional bioinformatics approaches—including tumor microenvironment characterization, survival pattern evaluation, and differential expression profiling—through multiple bladder cancer datasets from TCGA and GEO repositories, with subsequent experimental validation employing in vitro cellular models.</p> Results <p>Our findings demonstrate that FSTL1 exhibits significant overexpression in bladder tumors, promotes cancer cell motility through pro-migratory mechanisms, and potentially modulates key components of the tumor microenvironment.</p> Conclusion <p>FSTL1 might be a therapeutic target or biomarker for the advancement of bladder cancer.</p>

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High FSTL1 expression promotes bladder cancer progression by enhancing tumor cell migration

  • 期刊论文

  • 发表日期：

    2025年7月14日

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  • Helin Zhang,
  • Xingxing Zhang,
  • Yuelin Du,
  • Wei Xiong,
  • Xiaojun Zhang,
  • Biao Zhang,
  • Panfeng Shang

摘要

Objective

Emerging evidence highlights diverse roles of FSTL1 across various malignancies, though its biological significance in bladder carcinogenesis remains unexplored.

Methods

This study systematically interrogated FSTL1 using multidimensional bioinformatics approaches—including tumor microenvironment characterization, survival pattern evaluation, and differential expression profiling—through multiple bladder cancer datasets from TCGA and GEO repositories, with subsequent experimental validation employing in vitro cellular models.

Results

Our findings demonstrate that FSTL1 exhibits significant overexpression in bladder tumors, promotes cancer cell motility through pro-migratory mechanisms, and potentially modulates key components of the tumor microenvironment.

Conclusion

FSTL1 might be a therapeutic target or biomarker for the advancement of bladder cancer.