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Purpose <p>Numerous health-related quality of life (HRQoL) questionnaires are available to assess oral HRQoL in patients undergoing treatment for head and neck (H&amp;N) cancer. These multidimensional instruments should have the capacity to detect meaningful clinical oral function/dental changes at different time points. However, the optimal instrument—or combination of instruments—for assessing oral health and dental needs is not clear. We administered three questionnaires (FACT H&amp;N, EORTC QLQ-H&amp;N43, Orthognathic-QLQ) to assess oral and dental HRQoL in a cohort of H&amp;N cancer patients at 1-, 5- and 10-year post-treatment. A secondary aim was to compare these questionnaires to determine which provides the most useful assessment of oral HRQoL and dental care needs.</p> Methods <p>Prospective, single-center study of patients (<i>n</i> = 82) with H&amp;N cancer grouped according to the follow-up time (1, 5, or 10&#xa0;years). HRQoL was assessed by telephone with the Functional Assessment of Cancer Therapy (FACT H&amp;N), the European Organization for Research and Treatment (EORTC QLQ-H&amp;N43), and the Orthognathic Questionnaire (OQLQ). Analyses were performed to assess differences between groups.</p> Results <p>Eighty-two patients (fifty-nine men) were included. The mean age was 61.9&#xa0;years. On the EORTC QLQ-H&amp;N43, significant between-group differences (1&#xa0;year vs. 5 and 10&#xa0;years) were observed on five multi-item scales (mouth pain, senses, body image, anxiety, and shoulder problems) and on three single-item scales (neurological problems, neck swelling, and weight loss), indicating that QoL for those domains was more negatively impacted at 1-year post-treatment. Adjusted mean scores on most items on the EORTC QLQ-H&amp;N43 were similar in the 5- and 10-year groups. On the other two scales (FACT H&amp;N and OQLG), there were no significant between-group (1, 5, 10&#xa0;years) differences in adjusted mean scores.</p> Conclusion <p>These results show that the negative impact of H&amp;N cancer on HRQoL is most evident at 1-year versus 5- or 10-year post-treatment. The combined administration of the EORTC QLQ-H&amp;N43 and the OQLQ appear to provide the most useful assessment of HRQoL.</p>

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Assessing oral and dental health-related quality of life in head and neck cancer patients at 1, 5, and 10 years: a comparison of the EORTC QLQ43, FACT H&N, and the Orthognathic-QLQ questionnaires

  • 期刊论文

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  • 发表日期：

    2025年4月10日

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  • Marc Guedea,
  • Meritxell Sánchez,
  • Alicia Lozano,
  • Montse Ferrer,
  • Angels Pont,
  • Sandra Clotet,
  • Marc Juárez,
  • Isabel Linares,
  • Pablo Araguas,
  • Montse Ventura,
  • Nuno Gustavo d’Oliveira,
  • Maria Cristina Manzanares,
  • Josep Maria Ustrell,
  • Ferran Guedea

摘要

Purpose

Numerous health-related quality of life (HRQoL) questionnaires are available to assess oral HRQoL in patients undergoing treatment for head and neck (H&N) cancer. These multidimensional instruments should have the capacity to detect meaningful clinical oral function/dental changes at different time points. However, the optimal instrument—or combination of instruments—for assessing oral health and dental needs is not clear. We administered three questionnaires (FACT H&N, EORTC QLQ-H&N43, Orthognathic-QLQ) to assess oral and dental HRQoL in a cohort of H&N cancer patients at 1-, 5- and 10-year post-treatment. A secondary aim was to compare these questionnaires to determine which provides the most useful assessment of oral HRQoL and dental care needs.

Methods

Prospective, single-center study of patients (n = 82) with H&N cancer grouped according to the follow-up time (1, 5, or 10 years). HRQoL was assessed by telephone with the Functional Assessment of Cancer Therapy (FACT H&N), the European Organization for Research and Treatment (EORTC QLQ-H&N43), and the Orthognathic Questionnaire (OQLQ). Analyses were performed to assess differences between groups.

Results

Eighty-two patients (fifty-nine men) were included. The mean age was 61.9 years. On the EORTC QLQ-H&N43, significant between-group differences (1 year vs. 5 and 10 years) were observed on five multi-item scales (mouth pain, senses, body image, anxiety, and shoulder problems) and on three single-item scales (neurological problems, neck swelling, and weight loss), indicating that QoL for those domains was more negatively impacted at 1-year post-treatment. Adjusted mean scores on most items on the EORTC QLQ-H&N43 were similar in the 5- and 10-year groups. On the other two scales (FACT H&N and OQLG), there were no significant between-group (1, 5, 10 years) differences in adjusted mean scores.

Conclusion

These results show that the negative impact of H&N cancer on HRQoL is most evident at 1-year versus 5- or 10-year post-treatment. The combined administration of the EORTC QLQ-H&N43 and the OQLQ appear to provide the most useful assessment of HRQoL.