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<p>Stroke is a cerebrovascular condition that has emerged as the major cause of death globally, among other non-communicable diseases, due to its pathophysiological complexity and varied etiologies. Ischemic stroke (IS) represents the most prevalent subtype accounting for more than 70% of all stroke cases worldwide. The gut microbiome is considered the most abundant pool of microorganisms, which release metabolic products that facilitate gut-brain signaling. Despite advancements, the precise processes by which gut microbes influence stroke pathogenesis are not entirely understood. This review explores the immunomodulatory impact of gut-derived metabolites in IS, with a focus on short-chain fatty acids (SCFAs) and other bioactive substances. A comprehensive literature search was undertaken using MeSH terms such as gut microbiome, ischemic stroke, cerebral ischemia, brain infarction, intestinal flora, and&#xa0;gut-brain axis. We address how metabolites such as&#xa0;short-chain fatty acids produced by gut bacteria influence the host's immune system, which in turn affects the activity of neural networks linked to atherosclerosis, a major underlying mechanism of IS. Furthermore, this review also looks at new research opportunities and highlights evidence from studies conducted on humans and animals.</p>

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Crossroad Between Gut Microbiome and Ischemic Stroke: Underlying Pathways and Therapeutic Possibilities

  • 期刊论文

  • 发表日期：

    2025年11月25日

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  • Shivashish Dobhal,
  • Meenakshi Kaushik,
  • Prem Lata Manhas,
  • Ankur Kumar,
  • Priyanka Naithani,
  • Prakamya Gupta,
  • Hitaishi Kaushik,
  • Manisha Naithani,
  • Balram Ji Omar,
  • Ashish Kothari,
  • Akshat Uniyal,
  • Yogendra Pratap Mathuria,
  • Himanshu Kohli,
  • Hardeep Singh Manhas,
  • Jitender Gairolla

摘要

Stroke is a cerebrovascular condition that has emerged as the major cause of death globally, among other non-communicable diseases, due to its pathophysiological complexity and varied etiologies. Ischemic stroke (IS) represents the most prevalent subtype accounting for more than 70% of all stroke cases worldwide. The gut microbiome is considered the most abundant pool of microorganisms, which release metabolic products that facilitate gut-brain signaling. Despite advancements, the precise processes by which gut microbes influence stroke pathogenesis are not entirely understood. This review explores the immunomodulatory impact of gut-derived metabolites in IS, with a focus on short-chain fatty acids (SCFAs) and other bioactive substances. A comprehensive literature search was undertaken using MeSH terms such as gut microbiome, ischemic stroke, cerebral ischemia, brain infarction, intestinal flora, and gut-brain axis. We address how metabolites such as short-chain fatty acids produced by gut bacteria influence the host's immune system, which in turn affects the activity of neural networks linked to atherosclerosis, a major underlying mechanism of IS. Furthermore, this review also looks at new research opportunities and highlights evidence from studies conducted on humans and animals.