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<p><i>Delftia tsuruhatensis</i> IICT-RSP4, an uricase producing bacterium was isolated using <i>i</i>-chip method from soil and characterized. Here, we report the draft genome sequence of <i>D. tsuruhatensis</i> IICT-RSP4. The genome data comprised of 6,627,718&#xa0;bp (6.6&#xa0;MB) with a GC content of 66.6% with 7 protein encoding genes, 346 sub-systems with 6165 coding sequences and 112 RNAs. The genome revealed five functional secondary metabolite biosynthetic gene clusters viz. terpene, resorcinol, NRP + PKS, T2PKS, and RiPPS related to antimicrobial, anticancer and antimalarial functionality. In vitro, screening studies revealed the uricase potential of the strain <i>D. tsuruhatensis</i> IICT-RSP4 and has been supported by tblastn analysis. This is the first report on the whole genome sequence of an uricase-producing <i>D. tsuruhatensis</i> IICT-RSP4.</p>

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Draft Genome Analysis of Delftia tsuruhatensis IICT-RSP4, a Strain with Uricase Potential Isolated from Soil

  • 期刊论文

  • 发表日期：

    2025年1月7日

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  • Mahesh Anumalla,
  • Uma Rajeswari Batchu,
  • Nitesh Kumar Singh,
  • Bhima Bhukya,
  • Prakasham Reddy Shetty

摘要

Delftia tsuruhatensis IICT-RSP4, an uricase producing bacterium was isolated using i-chip method from soil and characterized. Here, we report the draft genome sequence of D. tsuruhatensis IICT-RSP4. The genome data comprised of 6,627,718 bp (6.6 MB) with a GC content of 66.6% with 7 protein encoding genes, 346 sub-systems with 6165 coding sequences and 112 RNAs. The genome revealed five functional secondary metabolite biosynthetic gene clusters viz. terpene, resorcinol, NRP + PKS, T2PKS, and RiPPS related to antimicrobial, anticancer and antimalarial functionality. In vitro, screening studies revealed the uricase potential of the strain D. tsuruhatensis IICT-RSP4 and has been supported by tblastn analysis. This is the first report on the whole genome sequence of an uricase-producing D. tsuruhatensis IICT-RSP4.