<p>Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an uncommon, benign reactive ulcerative oral mucosal lesion characterized by a self-limiting clinical course and a tendency to mimic malignant ulcerative lesions. Clinically, this lesion presents as a chronic, non-healing ulcer with indurated or rolled-out margins and a yellowish fibrinous base often mimicking oral squamous cell carcinoma. An accurate understanding of its clinicopathological and immunohistochemical profiling is essential to prevent misdiagnosis. The present study was thus aimed to evaluate the demographic, clinicopathological and immunohistochemical profiles of oral TUGSE over a period of 20 years. After obtaining clearance from the institutional human ethical clearance committee, fifteen uncommon cases of TUGSE were retrieved from the departmental archives. The clinical, demographic, and histopathological characteristics were recorded, and all the cases were subjected to CD3, CD20, CD68 and CD30 immunostaining. Data were analyzed descriptively using SPSS software version 26. Fifteen cases were identified with a mean age of 53.1 years. A slight female predominance was noted, and the lateral border of the tongue was the commonly affected site. A provisional diagnosis of malignant ulcer was given for all the cases. Histopathologically, all cases showed dense eosinophilic inflammatory infiltrate extending deep into connective tissue and skeletal muscle. Immunohistochemistry revealed consistent diffuse positivity for CD68 and CD3, while CD20 and CD30 exhibited focal positivity. TUGSE frequently mimics malignancy, emphasizing the importance of clinicopathological correlation and immunohistochemical analysis for differential diagnosis and appropriate management. The lesion resolves spontaneously post-biopsy and is self-limiting, which may be directly correlated with the presence of activated T cells and tissue macrophages.</p>