Scholarlink

<p>The primary objective of our study is to evaluate the impact of adverse pathological features on overall survival (OS) and disease-free survival (DFS) at 2 years in stage I and II oral cavity squamous cell carcinoma treated with upfront surgery. The secondary objective is to assess the pattern of recurrence based on adverse pathological features.&#xa0;Biopsy-proven early-stage oral cavity squamous cell carcinoma cases treated with upfront surgery at MVR Cancer Centre and Research Institute between January 1, 2017, and April 30, 2021, were included in the study. PNI, LVI, and WPOI-5 data for all patients were collected from the final histopathology reports. Patient follow up data were collected from electronic medical records (EMR), subjects/close relatives during OPD visits, and through phone calls.&#xa0;Our study found that DFS and OS were significantly associated with WPOI-5. In terms of the pattern of recurrence, a significant association was identified solely between regional failure and WPOI-5. Both PNI and LVI are not significant risk factors for DFS or OS at 2 years and have no significant association with locoregional failure in early-stage oral cancer.&#xa0;Our study concluded that WPOI-5 has a significant association with DFS, OS, and regional failure in early-stage oral cancer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of Adverse Pathological Features-Perineural Invasion (PNI), Lymphovascular Invasion (LVI) and Worst Pattern of Invasion- 5 (WPOI-5) on Overall Survival (OS) and Disease-Free Survival (DFS) at 2 Years in Stage I and II Oral Cavity Squamous Cell Carcinoma

  • 期刊论文

  • 发表日期：

    2026年6月22日

查看全文
  • Ameen Sumais AP,
  • Santhosh Kumar N,
  • Padma E,
  • Sudheesh Manoharan,
  • Bharathi K

摘要

The primary objective of our study is to evaluate the impact of adverse pathological features on overall survival (OS) and disease-free survival (DFS) at 2 years in stage I and II oral cavity squamous cell carcinoma treated with upfront surgery. The secondary objective is to assess the pattern of recurrence based on adverse pathological features. Biopsy-proven early-stage oral cavity squamous cell carcinoma cases treated with upfront surgery at MVR Cancer Centre and Research Institute between January 1, 2017, and April 30, 2021, were included in the study. PNI, LVI, and WPOI-5 data for all patients were collected from the final histopathology reports. Patient follow up data were collected from electronic medical records (EMR), subjects/close relatives during OPD visits, and through phone calls. Our study found that DFS and OS were significantly associated with WPOI-5. In terms of the pattern of recurrence, a significant association was identified solely between regional failure and WPOI-5. Both PNI and LVI are not significant risk factors for DFS or OS at 2 years and have no significant association with locoregional failure in early-stage oral cancer. Our study concluded that WPOI-5 has a significant association with DFS, OS, and regional failure in early-stage oral cancer.