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<p>Primary Hyperparathyroidism (PHPT) is a condition characterized by excessive secretion of parathormone (PTH), leading to hypercalcemia and associated complications, including cardiovascular dysfunction. Studies suggest that PHPT cause structural and functional cardiac changes including Left Ventricular Mass Index (LVMI), ejection fraction (LVEF), and diastolic function, with potential reversibility following parathyroidectomy. To assess the effect of parathyroidectomy on cardiac structure and function in PHPT patients without known risk factors. A prospective observational cohort study was conducted from July 2021 to August 2022. Sixteen patients undergoing parathyroidectomy for PHPT were recruited. Biochemical markers (serum calcium, iPTH, NT-pro BNP) and echocardiographic parameters (LVMI, LVEF, E/A ratio, IVRT, Posterior Wall (PW) thickness) were assessed preoperatively and three months postoperatively. Among the 16 patients (81% female, mean age 43 ± 10 years), 87% were symptomatic. Significant postoperative reductions were observed in serum calcium (p=0.001), iPTH (p=0.001), LVMI (p=0.044), and PW thickness (p=0.007). LVEF also improved significantly (p=0.010). However, no significant changes were noted in diastolic dysfunction parameters (IVRT, E/A ratio). Parathyroidectomy can have significant structural and functional change in PHPT patients, particularly by reducing LVMI &amp; PW thickness and enhancing LVEF. However, diastolic dysfunction may require longer follow-up for resolution. Further long term multicentric studies can help in strengthening the above findings.</p>

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Unburdening the Heart: Structural and Functional Cardiac Changes Post Parathyroidectomy for Primary Hyperparathyroidism

  • 期刊论文

  • 发表日期：

    2026年6月30日

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  • B. Sathishkumar,
  • Siddharth Manoj,
  • Vidhu Sharma,
  • Madhukar Mittal,
  • Ravindra Kumar Shukla,
  • Surender Deora,
  • Bikram Choudhury,
  • Amit Goyal,
  • Kapil Soni

摘要

Primary Hyperparathyroidism (PHPT) is a condition characterized by excessive secretion of parathormone (PTH), leading to hypercalcemia and associated complications, including cardiovascular dysfunction. Studies suggest that PHPT cause structural and functional cardiac changes including Left Ventricular Mass Index (LVMI), ejection fraction (LVEF), and diastolic function, with potential reversibility following parathyroidectomy. To assess the effect of parathyroidectomy on cardiac structure and function in PHPT patients without known risk factors. A prospective observational cohort study was conducted from July 2021 to August 2022. Sixteen patients undergoing parathyroidectomy for PHPT were recruited. Biochemical markers (serum calcium, iPTH, NT-pro BNP) and echocardiographic parameters (LVMI, LVEF, E/A ratio, IVRT, Posterior Wall (PW) thickness) were assessed preoperatively and three months postoperatively. Among the 16 patients (81% female, mean age 43 ± 10 years), 87% were symptomatic. Significant postoperative reductions were observed in serum calcium (p=0.001), iPTH (p=0.001), LVMI (p=0.044), and PW thickness (p=0.007). LVEF also improved significantly (p=0.010). However, no significant changes were noted in diastolic dysfunction parameters (IVRT, E/A ratio). Parathyroidectomy can have significant structural and functional change in PHPT patients, particularly by reducing LVMI & PW thickness and enhancing LVEF. However, diastolic dysfunction may require longer follow-up for resolution. Further long term multicentric studies can help in strengthening the above findings.