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<p>Nasal septal perforation (NSP) and saddle nose deformity are rare complications in paediatric patients, with potential associations to chemotherapy. This case study describes a 15-year-old male with pre-B acute lymphoblastic leukaemia (ALL) who developed asymptomatic NSP and saddle nose deformity six weeks after initiating the induction chemotherapy protocol, which included cytarabine (Ara-C), vincristine, and dexamethasone. Clinical examination revealed a 1 × 1&#xa0;cm anterior septal perforation and a small mass on the left middle turbinate. Biopsies and laboratory tests excluded infection, malignancy, and autoimmune causes. While the temporal association with Ara-C administration raises the possibility of chemotherapy-induced toxicity, a definitive causal relationship remains unconfirmed due to the absence of histopathological evidence of drug-specific damage. This case highlights the need for vigilance in monitoring pediatric oncology patients for atypical complications and further research to clarify potential etiologies.</p>

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Chemotherapy-Induced Nasal Septal Perforation and Saddle Nose Deformity in a Paediatric Leukaemia Patient

  • 期刊论文

  • 发表日期：

    2026年6月22日

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  • Dechen Lhamo,
  • Nurul Asma Che Ab Rahim,
  • Chen Jun Foo,
  • Jeyasakthy Saniasiaya

摘要

Nasal septal perforation (NSP) and saddle nose deformity are rare complications in paediatric patients, with potential associations to chemotherapy. This case study describes a 15-year-old male with pre-B acute lymphoblastic leukaemia (ALL) who developed asymptomatic NSP and saddle nose deformity six weeks after initiating the induction chemotherapy protocol, which included cytarabine (Ara-C), vincristine, and dexamethasone. Clinical examination revealed a 1 × 1 cm anterior septal perforation and a small mass on the left middle turbinate. Biopsies and laboratory tests excluded infection, malignancy, and autoimmune causes. While the temporal association with Ara-C administration raises the possibility of chemotherapy-induced toxicity, a definitive causal relationship remains unconfirmed due to the absence of histopathological evidence of drug-specific damage. This case highlights the need for vigilance in monitoring pediatric oncology patients for atypical complications and further research to clarify potential etiologies.