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<p>To assess the predictive value of early postoperative parathyroid hormone (PTH) levels in identifying patients at risk of hypocalcemia following total thyroidectomy and to identify correlation with subsequent serum calcium levels.&#xa0;Design: Prospective observational study. Setting: Department of Otorhinolaryngology in a tertiary health care setting in India. Subjects: 69 patients undergoing total thyroidectomy from April 2024 to April 2026, excluding those with pre-existing thyroid or parathyroid disorders affecting calcium metabolism. The present study comprehensively evaluated early postoperative parathyroid hormone (PTH) measurement at 3 hours following thyroidectomy and its correlation with postoperative calcium dynamics. The study integrates demographic parameters, radiological and cytological stratification systems, histopathological findings, and biochemical correlations.All patients underwent standardized total thyroidectomy with meticulous parathyroid preservation. Serum PTH was measured 3 hours postoperatively, and serum calcium was assessed at 48 hours and 7 days. Patients were clinically monitored for hypocalcemia. Data were analyzed using SPSS, with correlations between early PTH and postoperative calcium assessed; p&lt; 0.05 was considered significant.&#xa0;A significant decline in serum calcium was observed at 48 hours postoperatively, with partial recovery by day 7. Age, gender, thyroid pathology, and preoperative calcium did not significantly influence postoperative calcium or PTH levels. A positive correlation was found between 3-hour PTH and both 48-hour and 7-day calcium levels. Early PTH decline accurately identified patients at risk for symptomatic or biochemical hypocalcemia, enabling timely calcium and vitamin D supplementation.&#xa0;Early postoperative PTH measurement at 3 hours is a reliable predictor of post-thyroidectomy hypocalcemia. Its routine use facilitates targeted supplementation, reduces symptomatic hypocalcemia, supports safe early discharge, and enhances postoperative care efficiency.</p>

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Early Postoperative Parathyroid Hormone Assay as a Definitive Biomarker for Predicting Post-Thyroidectomy Hypocalcemia: A Prospective Analytical Study

  • 期刊论文

  • 发表日期：

    2026年6月19日

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  • Himalni Padmanaban,
  • Prasanna Kumar Saravanam

摘要

To assess the predictive value of early postoperative parathyroid hormone (PTH) levels in identifying patients at risk of hypocalcemia following total thyroidectomy and to identify correlation with subsequent serum calcium levels. Design: Prospective observational study. Setting: Department of Otorhinolaryngology in a tertiary health care setting in India. Subjects: 69 patients undergoing total thyroidectomy from April 2024 to April 2026, excluding those with pre-existing thyroid or parathyroid disorders affecting calcium metabolism. The present study comprehensively evaluated early postoperative parathyroid hormone (PTH) measurement at 3 hours following thyroidectomy and its correlation with postoperative calcium dynamics. The study integrates demographic parameters, radiological and cytological stratification systems, histopathological findings, and biochemical correlations.All patients underwent standardized total thyroidectomy with meticulous parathyroid preservation. Serum PTH was measured 3 hours postoperatively, and serum calcium was assessed at 48 hours and 7 days. Patients were clinically monitored for hypocalcemia. Data were analyzed using SPSS, with correlations between early PTH and postoperative calcium assessed; p< 0.05 was considered significant. A significant decline in serum calcium was observed at 48 hours postoperatively, with partial recovery by day 7. Age, gender, thyroid pathology, and preoperative calcium did not significantly influence postoperative calcium or PTH levels. A positive correlation was found between 3-hour PTH and both 48-hour and 7-day calcium levels. Early PTH decline accurately identified patients at risk for symptomatic or biochemical hypocalcemia, enabling timely calcium and vitamin D supplementation. Early postoperative PTH measurement at 3 hours is a reliable predictor of post-thyroidectomy hypocalcemia. Its routine use facilitates targeted supplementation, reduces symptomatic hypocalcemia, supports safe early discharge, and enhances postoperative care efficiency.