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<p>Weight loss during/after treatment of oropharyngeal squamous cell carcinoma (OPSCC) has been noted to negatively influence treatment outcomes. No predictive models exist for weight loss in OPSCC. This retrospective study utilized an OPSCC database with 99 cases undergoing definitive treatment from 2010 to 2017. Tumor and host variables predictive of BMI reduction were identified via logistic regression models and used to design a nomogram. The median age was 58 years. All cases were squamous cell carcinoma. Patients with BMI &lt; 18 had significantly worse overall survival (54% vs. 79%, <i>p</i> = 0.01). Dysphagia at presentation, gender, feeding tube dependence, chemotherapy, and definitive radiotherapy were associated with BMI reduction. Gender remained consistently associated with BMI reduction in multivariate analysis (OR: 5.06, 95% CI: 1.26–20.28). Gender, Dysphagia, feeding tube dependence, chemotherapy, and definitive radiotherapy had the highest predictive score of BMI loss during/after treatment on the nomogram. BMI loss was associated with significantly worse overall survival. A nomogram has been created to predict BMI loss in OPSCC patients during and after treatment, with higher scores reflecting with similar variables from multivariate analysis.</p>

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Nomogram to Predict Reduction in Body Mass Index in Patients Undergoing Definitive Treatment for Oropharyngeal Squamous Cell Carcinoma

  • 期刊论文

  • 发表日期：

    2026年5月8日

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  • Elizabeth Bryan,
  • Patrick Spiller,
  • Ivan A. Alvarez,
  • Srivatsa Surya Vasudevan,
  • Dauren Adilbay,
  • John Pang,
  • Cherie-Ann O. Nathan,
  • Ameya A. Asarkar

摘要

Weight loss during/after treatment of oropharyngeal squamous cell carcinoma (OPSCC) has been noted to negatively influence treatment outcomes. No predictive models exist for weight loss in OPSCC. This retrospective study utilized an OPSCC database with 99 cases undergoing definitive treatment from 2010 to 2017. Tumor and host variables predictive of BMI reduction were identified via logistic regression models and used to design a nomogram. The median age was 58 years. All cases were squamous cell carcinoma. Patients with BMI < 18 had significantly worse overall survival (54% vs. 79%, p = 0.01). Dysphagia at presentation, gender, feeding tube dependence, chemotherapy, and definitive radiotherapy were associated with BMI reduction. Gender remained consistently associated with BMI reduction in multivariate analysis (OR: 5.06, 95% CI: 1.26–20.28). Gender, Dysphagia, feeding tube dependence, chemotherapy, and definitive radiotherapy had the highest predictive score of BMI loss during/after treatment on the nomogram. BMI loss was associated with significantly worse overall survival. A nomogram has been created to predict BMI loss in OPSCC patients during and after treatment, with higher scores reflecting with similar variables from multivariate analysis.