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<p>Otitis media with effusion (OME) is a common cause of hearing impairment in children. ‘Recent evidence suggests a role for Vitamin D in immune regulation and susceptibility to ENT infections. This study aimed to evaluate the association between serum Vitamin D levels and Otitis media with effusion&#xa0;in children. Methodology: A prospective case control study was conducted among children ages 2 to 8 years in a tertiary care hospital, Chengalpattu. 50 children were enrolled in both cases and controls group respectively. Vitamin&#xa0;D levels were assessed in both the groups and the values were compared.&#xa0;Statistical analysis was performed using unpaired t-tests and chi-square tests. The mean age of cases was significantly higher than controls (6.7 ± 1.0 vs. 5.5 ± 1.2 years; p &lt; 0.001), and male predominance was observed among cases (76% vs. 56%; p = 0.04). Vitamin D levels were significantly lower in the case group compared to controls across all categories: deficiency (18.2 ± 4.5 vs. 22.6 ± 5.1 ng/mL; p = 0.001), insufficiency (24.7 ± 2.8 vs. 26.9 ± 3.0 ng/mL; p = 0.032), and normal levels (32.1 ± 3.6 vs. 34.8 ± 4.2 ng/mL; p = 0.040). The&#xa0;role of demographic and nutritional factors&#xa0;(Vitamin&#xa0;D) in the development or severity of otitis media with effusion was established. Routine Vitamin D assessment should be considered in children with persistent OME.</p>

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Vitamin D and Pediatric Otitis Media with Effusion: A Cross Sectional Study

  • 期刊论文

  • 发表日期：

    2026年4月28日

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  • Srinath Selvarajan,
  • D. Balaji,
  • R. B. Namasivaya Navin,
  • S. Prabakaran,
  • R. Muthukumar,
  • S. Rajasekaran,
  • K. Gowthame,
  • Sarath Kumar

摘要

Otitis media with effusion (OME) is a common cause of hearing impairment in children. ‘Recent evidence suggests a role for Vitamin D in immune regulation and susceptibility to ENT infections. This study aimed to evaluate the association between serum Vitamin D levels and Otitis media with effusion in children. Methodology: A prospective case control study was conducted among children ages 2 to 8 years in a tertiary care hospital, Chengalpattu. 50 children were enrolled in both cases and controls group respectively. Vitamin D levels were assessed in both the groups and the values were compared. Statistical analysis was performed using unpaired t-tests and chi-square tests. The mean age of cases was significantly higher than controls (6.7 ± 1.0 vs. 5.5 ± 1.2 years; p < 0.001), and male predominance was observed among cases (76% vs. 56%; p = 0.04). Vitamin D levels were significantly lower in the case group compared to controls across all categories: deficiency (18.2 ± 4.5 vs. 22.6 ± 5.1 ng/mL; p = 0.001), insufficiency (24.7 ± 2.8 vs. 26.9 ± 3.0 ng/mL; p = 0.032), and normal levels (32.1 ± 3.6 vs. 34.8 ± 4.2 ng/mL; p = 0.040). The role of demographic and nutritional factors (Vitamin D) in the development or severity of otitis media with effusion was established. Routine Vitamin D assessment should be considered in children with persistent OME.