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<p>The purpose of the study was to investigate the possible protective effect against the ototoxic effect of cisplatin, selenium and zinc as well as the comparison between them. Fifty (<i>n</i> = 50) adult male Wistar rats (weighing 300–400&#xa0;g) were used in the study. As previously stated, the experiment was split into two stages. Phase I sought to determine which of the two trace elements was more beneficial to the cochlea. For five days in a row, animals in group I (<i>n</i> = 10) were given intraperitoneal (i.p.) cisplatin at a dose of 3.5&#xa0;mg/kg. In group II (<i>n</i> = 10), zinc was administered transtympanically (right ear) at a dose of 15&#xa0;mg/kg in addition to intraperitoneal cisplatin (at the same dose as in group I). Together with cisplatin, animals in group III (<i>n</i> = 10) got 60&#xa0;mg/kg of selenium transtympanically (right ear). After the cisplatin treatments were finished, both zinc and selenium were also given for a further 14 days. Phase II concentrated on investigating the cochlea’s possible increased response to selenium-loaded nanoparticles. Selenium nanoparticles were administered in two different solutions, 10 rats received selenium nanoparticles dissolved in ethyl alcohol, while another ten received selenium nanoparticles dissolved in water. No trace element, no matter how it is delivered, offers total defense against the effects of cisplatin on the cochlea. In terms of protecting the cochlea, selenium seems to be modestly better than magnesium. For selenium nanoparticles, ethyl alcohol seems to be a slightly better solvent.</p>

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Exploring the Protective Role of Zinc and Selenium Against Cisplatin-Induced Cochleotoxicity: An Experimental Model in Rats

  • 期刊论文

  • 发表日期：

    2026年4月21日

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  • Pavlos Pavlidis,
  • Georgios Delis,
  • Kyriaki Papadopoulou,
  • Sofia Karachrysafi,
  • Eleni-Maria Christodoulou,
  • Vasilis Spyridon Tseriotis,
  • Dimitrios Kouvelas

摘要

The purpose of the study was to investigate the possible protective effect against the ototoxic effect of cisplatin, selenium and zinc as well as the comparison between them. Fifty (n = 50) adult male Wistar rats (weighing 300–400 g) were used in the study. As previously stated, the experiment was split into two stages. Phase I sought to determine which of the two trace elements was more beneficial to the cochlea. For five days in a row, animals in group I (n = 10) were given intraperitoneal (i.p.) cisplatin at a dose of 3.5 mg/kg. In group II (n = 10), zinc was administered transtympanically (right ear) at a dose of 15 mg/kg in addition to intraperitoneal cisplatin (at the same dose as in group I). Together with cisplatin, animals in group III (n = 10) got 60 mg/kg of selenium transtympanically (right ear). After the cisplatin treatments were finished, both zinc and selenium were also given for a further 14 days. Phase II concentrated on investigating the cochlea’s possible increased response to selenium-loaded nanoparticles. Selenium nanoparticles were administered in two different solutions, 10 rats received selenium nanoparticles dissolved in ethyl alcohol, while another ten received selenium nanoparticles dissolved in water. No trace element, no matter how it is delivered, offers total defense against the effects of cisplatin on the cochlea. In terms of protecting the cochlea, selenium seems to be modestly better than magnesium. For selenium nanoparticles, ethyl alcohol seems to be a slightly better solvent.