<p>Benign paroxysmal positional vertigo (BPPV) is one of the most common causes of peripheral vertigo. The aim of this study was to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the novel inflammatory indices systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) in patients with BPPV. This retrospective study included a patient group and a control group. The patient group consisted of 50 individuals who presented to the otorhinolaryngology clinic with complaints of dizziness between June 2024 and January 2025 and were diagnosed with BPPV using the Dix–Hallpike maneuver. The control group comprised 50 healthy individuals matched for age and sex. Patient data were obtained from the hospital information system. Demographic characteristics and hematological parameters, including NLR, PLR, SII, and SIRI, were compared between the two groups. Neutrophil, NLR, PLR, SII, and SIRI values were significantly higher in the BPPV group compared with the control group (<i>p</i> &lt; 0.05). In contrast, no statistically significant differences were observed between the groups in terms of leukocyte, lymphocyte, platelet, monocyte, or hemoglobin levels. The results of this study indicate that systemic inflammation is increased in patients with BPPV, as evidenced by elevated SII and SIRI values.</p>