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<p>Esthesioneuroblastoma (ENB) is a rare and malignant small round blue cell tumor that typically arises from the olfactory epithelium in the nasal cavity (Thompson in Mod Pathol 30:S1–26, 2017). It represents approximately 2–3% of all sinonasal tumors. Most commonly, ENB originates from the cribriform plate (Thompson in Head Neck Pathol 3(3):252–259, 2009); however, lateral nasal wall involvement is relatively uncommon. It is a locally aggressive malignancy that frequently invades the skull base and orbit. Regional and distant metastases occur in 14% to 38% of patients, most commonly to cervical lymph nodes, lung, and bones (Ghaffar and Salahuddin in Ear Nose Throat J 84(3):150–152, 2005). It occurs almost equally in males and females. We present a case of a 64-year-old female who presented with a 2-year history of right-sided nasal obstruction, along with a mass protruding from the right side of the nose and other related symptoms, including nasal discharge, swelling, and hyposmia. Imaging revealed an aggressive, heterogeneously enhancing mass extending from the lateral nasal wall into adjacent structures. Histopathological examination confirmed the diagnosis of ENB, which is classified as Kadish Stage C. The patient underwent endoscopic resection of the tumor under general anaesthesia and was planned for postoperative radiotherapy. The patient showed no recurrence of tumor during follow-up visits and was symptomatically improved, along with improvement of quality of life. This case emphasizes the importance of considering rare tumor origins in the differential diagnosis of sinonasal malignancies and highlights the need for multimodal treatment in advanced-stage cases.</p>

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Esthesioneuroblastoma of the Lateral Nasal Wall: A Rare Origin for a Rare Tumor

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Anjan K. Sahoo,
  • Twisha Chatterjee,
  • Harshit Wadbude

摘要

Esthesioneuroblastoma (ENB) is a rare and malignant small round blue cell tumor that typically arises from the olfactory epithelium in the nasal cavity (Thompson in Mod Pathol 30:S1–26, 2017). It represents approximately 2–3% of all sinonasal tumors. Most commonly, ENB originates from the cribriform plate (Thompson in Head Neck Pathol 3(3):252–259, 2009); however, lateral nasal wall involvement is relatively uncommon. It is a locally aggressive malignancy that frequently invades the skull base and orbit. Regional and distant metastases occur in 14% to 38% of patients, most commonly to cervical lymph nodes, lung, and bones (Ghaffar and Salahuddin in Ear Nose Throat J 84(3):150–152, 2005). It occurs almost equally in males and females. We present a case of a 64-year-old female who presented with a 2-year history of right-sided nasal obstruction, along with a mass protruding from the right side of the nose and other related symptoms, including nasal discharge, swelling, and hyposmia. Imaging revealed an aggressive, heterogeneously enhancing mass extending from the lateral nasal wall into adjacent structures. Histopathological examination confirmed the diagnosis of ENB, which is classified as Kadish Stage C. The patient underwent endoscopic resection of the tumor under general anaesthesia and was planned for postoperative radiotherapy. The patient showed no recurrence of tumor during follow-up visits and was symptomatically improved, along with improvement of quality of life. This case emphasizes the importance of considering rare tumor origins in the differential diagnosis of sinonasal malignancies and highlights the need for multimodal treatment in advanced-stage cases.