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<p>Facial scarring, especially secondary to acne, remains a significant cosmetic concern. Microneedling (MN) has emerged as a promising technique for treating atrophic scars through controlled dermal injury and collagen stimulation. The adjunctive use of topical agents such as tranexamic acid (TXA) or hyaluronic acid (HA) may potentiate the regenerative effects of MN. This randomized clinical study aims to evaluate the comparative efficacy and safety of microneedling with topical tranexamic acid versus microneedling with hyaluronic acid in the management of facial scars. Fifty patients aged 18 to 45 years with moderate to severe facial atrophic scars were randomly assigned into two groups. Group A (n = 25) received microneedling with topical tranexamic acid, while Group B (n = 25) underwent microneedling with topical hyaluronic acid gel. Patients were treated in four sessions at three-week intervals. Scar severity was evaluated at baseline, after the final session, and three months post-treatment using Goodman and Baron’s qualitative grading scales. Patient satisfaction and side effects were also recorded. Both groups demonstrated statistically significant improvements in qualitative scar grading post-treatment (p &lt; 0.001). The mean percentage of qualitative improvement in Group A was 53.6% ± 13.9%, compared to 46.4% ± 15.2% in Group B (p = 0.048). Group A also showed higher levels of patient satisfaction, although the difference was not statistically significant. Adverse effects were mild and transient. Microneedling is an effective treatment modality for facial scars. The addition of topical tranexamic acid appears to enhance clinical outcomes more significantly than hyaluronic acid, suggesting its potential as a superior adjunctive agent in scar remodelling protocols.</p>

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Evaluating the Efficacy of Microneedling with and Without Tranexamic Acid in Facial Scar Management: A Randomized Clinical Study

  • 期刊论文

  • 发表日期：

    2026年3月26日

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  • Sapna Tandon,
  • Aakash kumar,
  • Himanshu Chauhan,
  • Hemant Mehra,
  • Ibtisam Sahin,
  • Pandey Kiran

摘要

Facial scarring, especially secondary to acne, remains a significant cosmetic concern. Microneedling (MN) has emerged as a promising technique for treating atrophic scars through controlled dermal injury and collagen stimulation. The adjunctive use of topical agents such as tranexamic acid (TXA) or hyaluronic acid (HA) may potentiate the regenerative effects of MN. This randomized clinical study aims to evaluate the comparative efficacy and safety of microneedling with topical tranexamic acid versus microneedling with hyaluronic acid in the management of facial scars. Fifty patients aged 18 to 45 years with moderate to severe facial atrophic scars were randomly assigned into two groups. Group A (n = 25) received microneedling with topical tranexamic acid, while Group B (n = 25) underwent microneedling with topical hyaluronic acid gel. Patients were treated in four sessions at three-week intervals. Scar severity was evaluated at baseline, after the final session, and three months post-treatment using Goodman and Baron’s qualitative grading scales. Patient satisfaction and side effects were also recorded. Both groups demonstrated statistically significant improvements in qualitative scar grading post-treatment (p < 0.001). The mean percentage of qualitative improvement in Group A was 53.6% ± 13.9%, compared to 46.4% ± 15.2% in Group B (p = 0.048). Group A also showed higher levels of patient satisfaction, although the difference was not statistically significant. Adverse effects were mild and transient. Microneedling is an effective treatment modality for facial scars. The addition of topical tranexamic acid appears to enhance clinical outcomes more significantly than hyaluronic acid, suggesting its potential as a superior adjunctive agent in scar remodelling protocols.