Scholarlink

<p>Oral cancer significantly impacts physical function and psychological well-being, leading to anxiety, depression, stress, and reduced quality of life (QOL). This study prospectively assessed psychological burden and QOL in oral cancer patients, evaluating changes over time, the influence of psychological counseling, and differences across treatment modalities.&#xa0;This prospective, longitudinal, observational study enrolled 100 patients aged ≥ 18 years with histopathologically confirmed oral squamous cell carcinoma at tertiary centers in Shimla, India, from March 2022 to January 2024. Assessments using the Depression, Anxiety, and Stress Scale (DASS-21) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck module (EORTC QLQ-H&amp;N43) were conducted at baseline (diagnosis), 2 weeks, 1 month, and 6 months post-treatment. Fifty patients received psychological counseling (weekly sessions focusing on coping strategies). Data were analyzed using SPSS 19.0, with repeated measures ANOVA for temporal changes and group comparisons (<i>p</i> &lt; 0.05 significant).&#xa0;Patients were predominantly male (88%), mean age 54.76 ± 13.23 years, with combination therapy most common (82%). Depression increased from 2.84 ± 1.40 to 15.01 ± 2.45 (<i>p</i> &lt; 0.001), anxiety decreased from 13.13 ± 2.96 to 4.51 ± 1.35 (<i>p</i> &lt; 0.001), and stress increased from 5.78 ± 2.29 to 10.84 ± 3.29 (<i>p</i> &lt; 0.001). QOL scores improved from 50.00 ± 12.19 to 138.60 ± 16.43 (<i>p</i> &lt; 0.001). Counselled patients exhibited lower 6-month depression (14.00 ± 2.30 vs. 16.02 ± 2.40, <i>p</i> &lt; 0.01) and stress (9.50 ± 3.00 vs. 12.18 ± 3.30, <i>p</i> &lt; 0.001), with greater anxiety reduction (group×time interaction <i>p</i> &lt; 0.01). Combination therapy was associated with higher 6-month depression (15.50 ± 2.50) and stress (11.20 ± 3.30) compared to surgery alone (12.00 ± 2.00 and 8.00 ± 2.00, respectively; <i>p</i> &lt; 0.05).&#xa0;Oral cancer exacerbates psychological distress, but counseling mitigates this burden. Multidisciplinary care integrating psychological support is crucial for enhancing QOL and outcomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comprehensive Evaluation of Psychological Burden and Quality of Life in Oral Cancer Patients: A Multidisciplinary Approach to Treatment and Recovery

  • 期刊论文

  • 发表日期：

    2026年3月21日

查看全文
  • Abhijeet kamble,
  • Rangila Ram,
  • Manish Sahore,
  • Narotam Ghezta

摘要

Oral cancer significantly impacts physical function and psychological well-being, leading to anxiety, depression, stress, and reduced quality of life (QOL). This study prospectively assessed psychological burden and QOL in oral cancer patients, evaluating changes over time, the influence of psychological counseling, and differences across treatment modalities. This prospective, longitudinal, observational study enrolled 100 patients aged ≥ 18 years with histopathologically confirmed oral squamous cell carcinoma at tertiary centers in Shimla, India, from March 2022 to January 2024. Assessments using the Depression, Anxiety, and Stress Scale (DASS-21) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck module (EORTC QLQ-H&N43) were conducted at baseline (diagnosis), 2 weeks, 1 month, and 6 months post-treatment. Fifty patients received psychological counseling (weekly sessions focusing on coping strategies). Data were analyzed using SPSS 19.0, with repeated measures ANOVA for temporal changes and group comparisons (p < 0.05 significant). Patients were predominantly male (88%), mean age 54.76 ± 13.23 years, with combination therapy most common (82%). Depression increased from 2.84 ± 1.40 to 15.01 ± 2.45 (p < 0.001), anxiety decreased from 13.13 ± 2.96 to 4.51 ± 1.35 (p < 0.001), and stress increased from 5.78 ± 2.29 to 10.84 ± 3.29 (p < 0.001). QOL scores improved from 50.00 ± 12.19 to 138.60 ± 16.43 (p < 0.001). Counselled patients exhibited lower 6-month depression (14.00 ± 2.30 vs. 16.02 ± 2.40, p < 0.01) and stress (9.50 ± 3.00 vs. 12.18 ± 3.30, p < 0.001), with greater anxiety reduction (group×time interaction p < 0.01). Combination therapy was associated with higher 6-month depression (15.50 ± 2.50) and stress (11.20 ± 3.30) compared to surgery alone (12.00 ± 2.00 and 8.00 ± 2.00, respectively; p < 0.05). Oral cancer exacerbates psychological distress, but counseling mitigates this burden. Multidisciplinary care integrating psychological support is crucial for enhancing QOL and outcomes.