Scholarlink

<p>To investigate the association of the TFRC promoter variant rs11915082 and the missense variant rs3817672 with precancerous oral lesions. A comparative study included 300 participants: 100 with OSMF, 100 with leukoplakia, and 100 healthy controls. Genotyping was conducted using PCR-RFLP to analyze the association of SNP genotypes and allele frequencies with the diseases. Smokers showed higher prevalence rates of OSMF (72%) and leukoplakia (62%) compared to healthy controls (48%), with tobacco chewers also exhibiting elevated rates of OSMF (59%) and leukoplakia (61%). Chewing and smoking habits showed significant risk for oral potentially malignant disorders. The rs11915082 variant showed AA genotype distributions of 19% in OSMF and 31% in leukoplakia, while the TT genotype of rs3817672 was more prevalent in OSMF (41%) than in leukoplakia (21%). Although the AA genotype had insignificant odds ratios, the TT genotype had significant associations (ORs 9.46 and 3.0) and T allele were significantly higher p &lt; 0.001 in OSMF and leukoplakia, suggesting a genetic predisposition to these disorders. TFRC rs11915082 polymorphism was not significantly associated with OSMF or leukoplakia in the South Indian cohort, while the missense variant rs3817672 could be a valuable therapeutic marker for assessing oral premalignancy prognosis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Genetic Association Between TFRC Gene Polymorphism (rs11915082 and rs3817672) and Susceptibility to Oral Premalignant Disorder in South Indian Cohort

  • 期刊论文

  • 发表日期：

    2026年2月26日

查看全文
  • Usha Subbiah,
  • Nihala Sidhic

摘要

To investigate the association of the TFRC promoter variant rs11915082 and the missense variant rs3817672 with precancerous oral lesions. A comparative study included 300 participants: 100 with OSMF, 100 with leukoplakia, and 100 healthy controls. Genotyping was conducted using PCR-RFLP to analyze the association of SNP genotypes and allele frequencies with the diseases. Smokers showed higher prevalence rates of OSMF (72%) and leukoplakia (62%) compared to healthy controls (48%), with tobacco chewers also exhibiting elevated rates of OSMF (59%) and leukoplakia (61%). Chewing and smoking habits showed significant risk for oral potentially malignant disorders. The rs11915082 variant showed AA genotype distributions of 19% in OSMF and 31% in leukoplakia, while the TT genotype of rs3817672 was more prevalent in OSMF (41%) than in leukoplakia (21%). Although the AA genotype had insignificant odds ratios, the TT genotype had significant associations (ORs 9.46 and 3.0) and T allele were significantly higher p < 0.001 in OSMF and leukoplakia, suggesting a genetic predisposition to these disorders. TFRC rs11915082 polymorphism was not significantly associated with OSMF or leukoplakia in the South Indian cohort, while the missense variant rs3817672 could be a valuable therapeutic marker for assessing oral premalignancy prognosis.