<p>Moderate Persistent Rhinitis is a globally prevalent condition affecting approximately 15–20% of the population. Although fluticasone nasal spray is widely prescribed, silver nitrate offers an alternative approach with potential long-term benefits and fewer side effects. To compare the effectiveness of silver nitrate application versus fluticasone nasal spray in the treatment of Moderate Persistent Rhinitis. To assess the impact of silver nitrate application and fluticasone nasal spray on symptom scores and to evaluate the effect of both treatments on endoscopic findings in patients with Moderate Persistent Rhinitis over a period of 6&#xa0;months. A prospective interventional study of 120 patients diagnosed with Moderate Persistent Rhinitis was conducted. Patients were randomly assigned into two groups: Group A received weekly 25% silver nitrate application for one month, and Group B received fluticasone nasal spray twice daily for six months. Outcomes included symptom scores (SNOT-22), quality of life assessments, and endoscopic findings evaluated at baseline, 1, 3, and 6&#xa0;months. Both treatments were effective in reducing symptoms. However, 25% silver nitrate demonstrated superior symptom relief in sneezing (p = 0.01), nasal discharge (p = 0.03), and congestion (p = 0.01) and reduced the recurrence of symptoms. Improvements in sleep (p = 0.02) and daily activities (p = 0.01) were also significantly better in Group A. Silver nitrate (25%) offers a promising alternative to fluticasone for treating Moderate Persistent Rhinitis, with superior symptom control, patient satisfaction and control of recurrence of symptoms.</p>