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<p>This study aims to systematically review and characterise the clinical profile, management strategies, and prognosis of Ramsay-Hunt Syndrome (RHS) in paediatric populations, including children and adolescents. Following PRISMA guidelines, we searched PubMed, Scopus, and CINAHL Ultimate (with an additional search of Google Scholar and OpenGrey) up to 25 February 2025. The review included RHS-specific case reports and case series involving children and adolescents aged ≤ 20 years. From 755 screened articles, 57 reports on 68 patients met the inclusion criteria. The median age of patients was 12 years (IQR: 8–15), with males comprising 60.29% of cases. Facial palsy was universal (100%), vesicles were observed in 89.7% of cases, and 73.52% reported pain. Patients with a history of chickenpox (44.11%) showed a median gap of 7 years (IQR: 3.25–9.5) between infection and RHS onset, with older children demonstrating longer gaps (<i>r</i> = 0.67, <i>p</i> = 0.05). Antivirals were prescribed in 88.23% of cases. The preferred antiviral was Acyclovir, which was used in 91.52% of these cases. Corticosteroids were used in 82.35%, with prednisolone as the preferred agent. Partial recovery, including persistent facial paralysis (43.75%), was observed in 22.05%, predominantly in older children (median age 14 years, <i>p</i> = 0.056). Complications were identified in 11.76%, including conjunctivitis, meningitis, and otitis media. Early combination therapy with antivirals and corticosteroids significantly improves RHS outcomes in children. The proposed treatment protocol standardises management by recommending comprehensive care.</p>

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Ramsay-Hunt Syndrome in Childhood: A Systematic Review and Treatment Update

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • H. Shafeeq Ahmed,
  • Purva Reddy Jayaram,
  • Sakshi C. Choradia,
  • Roshan Agarwal,
  • Girish Srinivasa,
  • Rishika Das

摘要

This study aims to systematically review and characterise the clinical profile, management strategies, and prognosis of Ramsay-Hunt Syndrome (RHS) in paediatric populations, including children and adolescents. Following PRISMA guidelines, we searched PubMed, Scopus, and CINAHL Ultimate (with an additional search of Google Scholar and OpenGrey) up to 25 February 2025. The review included RHS-specific case reports and case series involving children and adolescents aged ≤ 20 years. From 755 screened articles, 57 reports on 68 patients met the inclusion criteria. The median age of patients was 12 years (IQR: 8–15), with males comprising 60.29% of cases. Facial palsy was universal (100%), vesicles were observed in 89.7% of cases, and 73.52% reported pain. Patients with a history of chickenpox (44.11%) showed a median gap of 7 years (IQR: 3.25–9.5) between infection and RHS onset, with older children demonstrating longer gaps (r = 0.67, p = 0.05). Antivirals were prescribed in 88.23% of cases. The preferred antiviral was Acyclovir, which was used in 91.52% of these cases. Corticosteroids were used in 82.35%, with prednisolone as the preferred agent. Partial recovery, including persistent facial paralysis (43.75%), was observed in 22.05%, predominantly in older children (median age 14 years, p = 0.056). Complications were identified in 11.76%, including conjunctivitis, meningitis, and otitis media. Early combination therapy with antivirals and corticosteroids significantly improves RHS outcomes in children. The proposed treatment protocol standardises management by recommending comprehensive care.