<p>Long duration head and neck cancer surgeries are common surgical procedures that can lead to decrease in albumin levels due to multiple reasons. Hypoalbuminemia has been linked to poor wound healing, increased mortality, and postoperative complications such as surgical site infection, reoperations and longer hospital stays. Early postoperative albumin drop has been associated with adverse outcomes in various surgical specialties, but its role in head and neck surgeries has not been extensively studied. A prospective observational study was conducted on 100 patients undergoing elective head and neck cancer surgeries with a duration of more than 6&#xa0;h. Preoperative and postoperative albumin levels were measured, and Δ albumin was calculated. The association between delta (Δ) albumin and postoperative complications, including fever, long hospital stays, ICU admission, requirement of ventilation, pleural effusion, pulmonary edema, wound dehiscence, wound infection, re exploration and mortality was analyzed using appropriate statistical methods. Higher Δ albumin ranges (31–40%, 41–50%, and 51–60%) were significantly associated with postoperative complications (<i>p</i> &lt; 0.05). Δ albumin of 14.77% and above was identified as a significant associated with of adverse outcomes (<i>p</i> = 0.04). Δ albumin is a significant associated with of adverse outcomes in long duration elective head and neck surgeries. Patients with a high preoperative albumin decline are at greater risk of developing postoperative complications. Measuring Δ albumin can help identify patients who may benefit from more intensive postoperative monitoring and early intervention.</p>