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<p>Acantholytic squamous cell carcinoma (aSCC) is a rare clinicopathological subtype of cutaneous squamous cell carcinoma, accounting for approximately 4.9% of all SCC cases. Areas of the skin that are exposed to sunlight are the usual locations for ASCC to appear. This systematic review is the first to summarize the clinical and molecular features of oral aSCC. A systematic search of Medline, Embase, Scopus, and PubMed was performed. All articles in English were included, with no restriction of publication date. All articles with original data pertaining to clinical or molecular characteristics of aSCC were included. Two reviewers screened articles and resolved conflicts. Present systematic review included 29 studies on the clinical and molecular features of aSCC, including a total of 126 patients (66.1% male, mean age at diagnosis 50 years). The most common location of aSCC of oral cavity was tongue followed by buccal mucosa. Twelve studies discussed the immunohistochemical markers of aSCC, with the most prevalent markers being Cytokeratins (positive for 75% of the cases). CD15 negativity was noted, while common endothelial vascular markers such as CD34, CD31, factor VIII-related antigen, and ERG were often not expressed. Finally, expression of intracellular adhesion molecules (i.e., E-cadherin, CD138) was markedly decreased compared to non-acantholytic invasive SCC. This systematic review summarizes the clinical characteristics and molecular features of aSCC. As clinical differentiation can be difficult, clinicopathological correlation with molecular markers may help ensure proper diagnosis.</p>

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Clinical, Immunohistochemical and Molecular Features of Oral Acantholytic Squamous Cell Carcinoma: A Systematic Review

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Gitika Sharma,
  • Aashish Mittal

摘要

Acantholytic squamous cell carcinoma (aSCC) is a rare clinicopathological subtype of cutaneous squamous cell carcinoma, accounting for approximately 4.9% of all SCC cases. Areas of the skin that are exposed to sunlight are the usual locations for ASCC to appear. This systematic review is the first to summarize the clinical and molecular features of oral aSCC. A systematic search of Medline, Embase, Scopus, and PubMed was performed. All articles in English were included, with no restriction of publication date. All articles with original data pertaining to clinical or molecular characteristics of aSCC were included. Two reviewers screened articles and resolved conflicts. Present systematic review included 29 studies on the clinical and molecular features of aSCC, including a total of 126 patients (66.1% male, mean age at diagnosis 50 years). The most common location of aSCC of oral cavity was tongue followed by buccal mucosa. Twelve studies discussed the immunohistochemical markers of aSCC, with the most prevalent markers being Cytokeratins (positive for 75% of the cases). CD15 negativity was noted, while common endothelial vascular markers such as CD34, CD31, factor VIII-related antigen, and ERG were often not expressed. Finally, expression of intracellular adhesion molecules (i.e., E-cadherin, CD138) was markedly decreased compared to non-acantholytic invasive SCC. This systematic review summarizes the clinical characteristics and molecular features of aSCC. As clinical differentiation can be difficult, clinicopathological correlation with molecular markers may help ensure proper diagnosis.