<p>Our primary aim is to evaluate the prognosis of higher tumor volume impact on the glottic and supraglottic tumor patients prognostic outcomes. Multiple databases comprising Pubmed, ScienceDirect, Embase and Web of Science were evaluated for articles reporting on prognostic outcomes associated with higher tumor volume in laryngeal tumors from inception to January 2025 were collected and reviewed. Meta-analysis was performed using a random-effects model to evaluate the local control rate, recurrence rate, and survival outcomes. Study quality assessment with sensitivity analysis and risk of bias was performed. Out of 1655 studies, 13 articles were included with 2789 laryngeal tumor patients (60.3% supraglottic, 39.7% glottic). For glottic tumors with higher tumor volume (median cut-off: 3.5 cm³), the pooled 5-year LCR was 73.9% (95% CI 62.0–83.0%). Supraglottic tumors with higher tumor volume (median cut-off: 9.7 cm³) had a lower pooled 5-year LCR of 42.6% (95% CI 16.6–73.5%). Higher tumor volume was linked to worsened 5-year OS (HR = 2.82, 95% CI 1.86–4.28, <i>p</i> &lt; 0.0001). Meta-regression revealed a significant positive association of improved 5-year LCR with recent publication years for supraglottic tumors with higher tumor volume (<i>p</i> = 0.0046). This systematic review shows that larger tumor volume negatively impacts local control rate in both glottic and supraglottic tumors. These findings emphasize the need for improved treatment strategies to enhance disease control.</p>