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<p>Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting condition predominantly impacting young women. It frequently resembles more severe illnesses, such as lymphoma or systemic lupus erythematosus (SLE), which complicates clinical diagnosis. We report a case of KFD in a 22-year-old female with Klippel-Feil Syndrome, who presented with fever and unilateral cervical lymphadenopathy. The diagnosis was validated by lymph node biopsy, which revealed distinctive histological characteristics. The patient was managed conservatively with antibiotics and analgesics, achieving complete recovery within one month.</p>

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Uncommon Convergence: Kikuchi-Fujimoto Disease in the Setting of Klippel-Feil Syndrome

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Mohana Vamsi Dhulipalla,
  • Reegan Jose Mathias,
  • Vinith Balaji Sekhar,
  • Arafath Iqbal,
  • Vivekananda Subramanianathan

摘要

Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting condition predominantly impacting young women. It frequently resembles more severe illnesses, such as lymphoma or systemic lupus erythematosus (SLE), which complicates clinical diagnosis. We report a case of KFD in a 22-year-old female with Klippel-Feil Syndrome, who presented with fever and unilateral cervical lymphadenopathy. The diagnosis was validated by lymph node biopsy, which revealed distinctive histological characteristics. The patient was managed conservatively with antibiotics and analgesics, achieving complete recovery within one month.