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<p>Head and neck squamous cell carcinoma (HNSCC) is a significant clinical problem worldwide, contributing to high morbidity and mortality. Even with modern therapies, patient outcomes remain unsatisfactory due to frequent recurrences and metastasis. The tumor-stroma ratio (TSR), indicating the proportion of stromal tissue relative to the total tumor area, has emerged as an important prognostic marker in various cancers. This study investigates the association between TSR and clinicopathological parameters in resected HNSCC cases. This retrospective cohort study included HNSCC patients who underwent resection from June 2022 to June 2024, excluding those with prior neoadjuvant therapy. TSR was calculated using hematoxylin and eosin-stained sections analyzed with Image-J software. TSR was categorized as low (&lt; 0.5) or high (≥ 0.5). Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) software, version 25.0, employing Mann-Whitney, Independent t-test, and Fisher’s exact test. Among 50 HNSCC cases, 31 had low TSR and 19 had high TSR. Cases with TSR &lt; 0.5 had a significantly higher median depth of invasion, advanced clinical stage, higher tumor stage, nodal involvement and lymphovascular invasion. No association was observed with age, gender, or perineural invasion. This study demonstrates that a low TSR is associated with more aggressive tumor characteristics in HNSCC, including higher tumor stage, nodal involvement, and lymphovascular invasion.</p>

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Evaluation of Tumor-Stroma Ratio in Head and Neck Squamous Cell Carcinoma

  • 期刊论文

  • 发表日期：

    2025年10月24日

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  • Sana Ahuja,
  • Sristi Barman,
  • Rakesh Kumar,
  • Aroonima Misra,
  • Sufian Zaheer

摘要

Head and neck squamous cell carcinoma (HNSCC) is a significant clinical problem worldwide, contributing to high morbidity and mortality. Even with modern therapies, patient outcomes remain unsatisfactory due to frequent recurrences and metastasis. The tumor-stroma ratio (TSR), indicating the proportion of stromal tissue relative to the total tumor area, has emerged as an important prognostic marker in various cancers. This study investigates the association between TSR and clinicopathological parameters in resected HNSCC cases. This retrospective cohort study included HNSCC patients who underwent resection from June 2022 to June 2024, excluding those with prior neoadjuvant therapy. TSR was calculated using hematoxylin and eosin-stained sections analyzed with Image-J software. TSR was categorized as low (< 0.5) or high (≥ 0.5). Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) software, version 25.0, employing Mann-Whitney, Independent t-test, and Fisher’s exact test. Among 50 HNSCC cases, 31 had low TSR and 19 had high TSR. Cases with TSR < 0.5 had a significantly higher median depth of invasion, advanced clinical stage, higher tumor stage, nodal involvement and lymphovascular invasion. No association was observed with age, gender, or perineural invasion. This study demonstrates that a low TSR is associated with more aggressive tumor characteristics in HNSCC, including higher tumor stage, nodal involvement, and lymphovascular invasion.