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<p>Herpes zoster (HZ) arises when dormant varicella-zoster virus (VZV) reactivates, typically affecting thoracic dermatomes; cranial nerve involvement is less frequent. Ramsay Hunt Syndrome (RHS) usually includes facial and vestibulocochlear nerves, while orofacial HZ targets the trigeminal nerve. This case describes a unique presentation in a 66-year-old immunocompetent male with simultaneous trigeminal (CN V) and vestibulocochlear (CN VIII) nerve involvement. The patient had vesicular eruptions over the face, oral mucosa, and pinna, and developed ipsilateral sensorineural hearing loss confirmed by audiometry. Management with antivirals and corticosteroids led to clinical improvement. This case underlines the need to identify unusual multiganglionic VZV reactivation promptly to prevent complications.</p>

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Orofacial Herpes Zoster Associated with Ipsilateral Sensorineural Hearing Loss: A Rare Amalgamation

  • 期刊论文

  • 发表日期：

    2025年10月24日

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  • Jaya Raje Gupta,
  • Shraddha Jain,
  • Megha Kawale,
  • Harshil Dobariya,
  • Ishita Rajesh Mrug

摘要

Herpes zoster (HZ) arises when dormant varicella-zoster virus (VZV) reactivates, typically affecting thoracic dermatomes; cranial nerve involvement is less frequent. Ramsay Hunt Syndrome (RHS) usually includes facial and vestibulocochlear nerves, while orofacial HZ targets the trigeminal nerve. This case describes a unique presentation in a 66-year-old immunocompetent male with simultaneous trigeminal (CN V) and vestibulocochlear (CN VIII) nerve involvement. The patient had vesicular eruptions over the face, oral mucosa, and pinna, and developed ipsilateral sensorineural hearing loss confirmed by audiometry. Management with antivirals and corticosteroids led to clinical improvement. This case underlines the need to identify unusual multiganglionic VZV reactivation promptly to prevent complications.