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<p>Introduction: Odontogenic keratocyst (OKC) is a benign but locally aggressive lesion with a high recurrence rate. Recent molecular studies have linked its pathogenesis to PTCH1 gene mutations and activation of the SHH signaling pathway, similar to basal cell carcinoma. This has led to the exploration of 5-fluorouracil (5-FU) as an adjunctive treatment. Case Report: A 22-year-old male with recurrent OKC in the mandibular anterior region was treated with enucleation, peripheral ostectomy, and topical application of 5% 5-FU. A gauze soaked in 5-FU was retained for 24&#xa0;h. Postoperative wound dehiscence was managed with a surgical stent. At 22-month follow-up, the patient showed satisfactory healing with no recurrence. Topical 5-FU appears to be a safe and effective adjunct in the conservative management of OKC, reducing recurrence risk and supporting tissue healing, particularly in recurrent or high-risk cases.</p>

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Mangement of Recurrent Odontogenic Keratocyst(OKC) Using 5-Flourouracil: A Case Report

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • Aneizo Khruomo,
  • Pooja Umathe,
  • Vikieo Khruomo

摘要

Introduction: Odontogenic keratocyst (OKC) is a benign but locally aggressive lesion with a high recurrence rate. Recent molecular studies have linked its pathogenesis to PTCH1 gene mutations and activation of the SHH signaling pathway, similar to basal cell carcinoma. This has led to the exploration of 5-fluorouracil (5-FU) as an adjunctive treatment. Case Report: A 22-year-old male with recurrent OKC in the mandibular anterior region was treated with enucleation, peripheral ostectomy, and topical application of 5% 5-FU. A gauze soaked in 5-FU was retained for 24 h. Postoperative wound dehiscence was managed with a surgical stent. At 22-month follow-up, the patient showed satisfactory healing with no recurrence. Topical 5-FU appears to be a safe and effective adjunct in the conservative management of OKC, reducing recurrence risk and supporting tissue healing, particularly in recurrent or high-risk cases.