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Objective <p>To investigate if differential ‘histological-vascularity’ signifying sectorial maturation in nasopharyngeal angiofibroma (NA) can define directional progression or clinical behaviour.</p> Methods <p>Histopathological-vascularity-pattern was assessed in whole specimen of 31 NA. The Vascularity-index(VI) was defined for central(C) and peripheral(P) zones. In addition, ‘Vascular-index-ratio’ (VIR) was defined as marker of maturation. The clinical parameters for correlation included age, duration, epistaxis, nasal-blockage, staging, intraoperative-haemorrhage and volume of tumour.</p> Results <p>VI in peripheral areas was higher than central region. A constant VIR despite variable VI suggests a comparable ongoing maturation. The important correlations were seen with duration, nasal blockage, age and Staging. Overall enhanced VI was evident along advancing front but VI as such reflected tumour-biology more than clinical-aggressiveness.</p> Conclusion <p>Sectorial maturation/ vascularization leading to directional progression is evident and higher VI may suggest likelihood of recurrence along a specific zone.</p>

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Maturation (Fibrosis) Pattern of Vasculature on Histology Defines Directional Progression in Nasopharyngeal Angiofibroma: Observational Study

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • Shalini Bhalla,
  • Rohit Verma,
  • Anupam Mishra

摘要

Objective

To investigate if differential ‘histological-vascularity’ signifying sectorial maturation in nasopharyngeal angiofibroma (NA) can define directional progression or clinical behaviour.

Methods

Histopathological-vascularity-pattern was assessed in whole specimen of 31 NA. The Vascularity-index(VI) was defined for central(C) and peripheral(P) zones. In addition, ‘Vascular-index-ratio’ (VIR) was defined as marker of maturation. The clinical parameters for correlation included age, duration, epistaxis, nasal-blockage, staging, intraoperative-haemorrhage and volume of tumour.

Results

VI in peripheral areas was higher than central region. A constant VIR despite variable VI suggests a comparable ongoing maturation. The important correlations were seen with duration, nasal blockage, age and Staging. Overall enhanced VI was evident along advancing front but VI as such reflected tumour-biology more than clinical-aggressiveness.

Conclusion

Sectorial maturation/ vascularization leading to directional progression is evident and higher VI may suggest likelihood of recurrence along a specific zone.